Childhood epilepsy and ADHD comorbidity in an Indian tertiary medical center outpatient population
This study aimed to assess the prevalence of Attention Deficit Hyperactivity Disorder (ADHD) and its characteristics and risk factors in children with epilepsy at a tertiary medical center in New Delhi. Children with active epilepsy, aged 6 to 12 years, were assessed for ADHD using DSM-IV-TR criteri...
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| Veröffentlicht in: | Scientific reports 2018-02, Vol.8 (1), p.2670-7, Article 2670 |
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| description | This study aimed to assess the prevalence of Attention Deficit Hyperactivity Disorder (ADHD) and its characteristics and risk factors in children with epilepsy at a tertiary medical center in New Delhi. Children with active epilepsy, aged 6 to 12 years, were assessed for ADHD using DSM-IV-TR criteria. Epilepsy and psychiatric characteristics, sociodemographic indicators, and use of antiepileptic drugs were analyzed for differences between the ADHD and non-ADHD groups. Among the 73 children with epilepsy, 23% (n = 17) had comorbid ADHD, of whom 59% (n = 10) had predominantly inattentive type, 35% (n = 6) combined type, and 6% (n = 1) predominantly hyperactive-impulsive type. Lower IQ scores, epileptiform EEG activity, not attending school, and male sex were significantly associated with comorbid ADHD in children with epilepsy. Groups were similar in terms of age, socioeconomic indicators, family history of psychiatric disorders, seizure frequency in the last six months, seizure etiology, and seizure type. Epilepsy is a common pediatric neurological condition with frequent psychiatric comorbidities, including ADHD. Specialists should collaborate to optimize treatment for children with epilepsy and ADHD, especially for families in developing countries where the burden of disease can be great. |
| doi_str_mv | 10.1038/s41598-018-20676-8 |
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Children with active epilepsy, aged 6 to 12 years, were assessed for ADHD using DSM-IV-TR criteria. Epilepsy and psychiatric characteristics, sociodemographic indicators, and use of antiepileptic drugs were analyzed for differences between the ADHD and non-ADHD groups. Among the 73 children with epilepsy, 23% (n = 17) had comorbid ADHD, of whom 59% (n = 10) had predominantly inattentive type, 35% (n = 6) combined type, and 6% (n = 1) predominantly hyperactive-impulsive type. Lower IQ scores, epileptiform EEG activity, not attending school, and male sex were significantly associated with comorbid ADHD in children with epilepsy. Groups were similar in terms of age, socioeconomic indicators, family history of psychiatric disorders, seizure frequency in the last six months, seizure etiology, and seizure type. Epilepsy is a common pediatric neurological condition with frequent psychiatric comorbidities, including ADHD. Specialists should collaborate to optimize treatment for children with epilepsy and ADHD, especially for families in developing countries where the burden of disease can be great.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-20676-8</identifier><identifier>PMID: 29422636</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/3187 ; 692/617/375/178 ; 692/617/375/366/1311 ; 692/699/375/178 ; 692/699/375/366/1311 ; Anticonvulsants - therapeutic use ; Antiepileptic agents ; Attention Deficit Disorder with Hyperactivity - physiopathology ; Attention Deficit Disorder with Hyperactivity - psychology ; Attention deficit hyperactivity disorder ; Child ; Childhood ; Children ; Cognition Disorders - complications ; Comorbidity ; Comorbidity - trends ; Convulsions & seizures ; Cross-Sectional Studies ; Developing countries ; EEG ; Epilepsy ; Epilepsy - complications ; Epilepsy - drug therapy ; Epilepsy - physiopathology ; Etiology ; Female ; Genetics ; Humanities and Social Sciences ; Humans ; Hyperactivity ; India - epidemiology ; LDCs ; Male ; Mental disorders ; multidisciplinary ; Outpatients ; Population studies ; Prevalence ; Psychiatric Status Rating Scales ; Retrospective Studies ; Risk factors ; Science ; Science (multidisciplinary) ; Seizures ; Seizures - drug therapy ; Severity of Illness Index</subject><ispartof>Scientific reports, 2018-02, Vol.8 (1), p.2670-7, Article 2670</ispartof><rights>The Author(s) 2018</rights><rights>2018. 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Children with active epilepsy, aged 6 to 12 years, were assessed for ADHD using DSM-IV-TR criteria. Epilepsy and psychiatric characteristics, sociodemographic indicators, and use of antiepileptic drugs were analyzed for differences between the ADHD and non-ADHD groups. Among the 73 children with epilepsy, 23% (n = 17) had comorbid ADHD, of whom 59% (n = 10) had predominantly inattentive type, 35% (n = 6) combined type, and 6% (n = 1) predominantly hyperactive-impulsive type. Lower IQ scores, epileptiform EEG activity, not attending school, and male sex were significantly associated with comorbid ADHD in children with epilepsy. Groups were similar in terms of age, socioeconomic indicators, family history of psychiatric disorders, seizure frequency in the last six months, seizure etiology, and seizure type. Epilepsy is a common pediatric neurological condition with frequent psychiatric comorbidities, including ADHD. Specialists should collaborate to optimize treatment for children with epilepsy and ADHD, especially for families in developing countries where the burden of disease can be great.</description><subject>692/308/3187</subject><subject>692/617/375/178</subject><subject>692/617/375/366/1311</subject><subject>692/699/375/178</subject><subject>692/699/375/366/1311</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Antiepileptic agents</subject><subject>Attention Deficit Disorder with Hyperactivity - physiopathology</subject><subject>Attention Deficit Disorder with Hyperactivity - psychology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Child</subject><subject>Childhood</subject><subject>Children</subject><subject>Cognition Disorders - complications</subject><subject>Comorbidity</subject><subject>Comorbidity - trends</subject><subject>Convulsions & seizures</subject><subject>Cross-Sectional Studies</subject><subject>Developing countries</subject><subject>EEG</subject><subject>Epilepsy</subject><subject>Epilepsy - 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therapeutic use</topic><topic>Antiepileptic agents</topic><topic>Attention Deficit Disorder with Hyperactivity - physiopathology</topic><topic>Attention Deficit Disorder with Hyperactivity - psychology</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Child</topic><topic>Childhood</topic><topic>Children</topic><topic>Cognition Disorders - complications</topic><topic>Comorbidity</topic><topic>Comorbidity - trends</topic><topic>Convulsions & seizures</topic><topic>Cross-Sectional Studies</topic><topic>Developing countries</topic><topic>EEG</topic><topic>Epilepsy</topic><topic>Epilepsy - complications</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - physiopathology</topic><topic>Etiology</topic><topic>Female</topic><topic>Genetics</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>India - epidemiology</topic><topic>LDCs</topic><topic>Male</topic><topic>Mental disorders</topic><topic>multidisciplinary</topic><topic>Outpatients</topic><topic>Population studies</topic><topic>Prevalence</topic><topic>Psychiatric Status Rating Scales</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Seizures</topic><topic>Seizures - drug therapy</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choudhary, Anita</creatorcontrib><creatorcontrib>Gulati, Sheffali</creatorcontrib><creatorcontrib>Sagar, Rajesh</creatorcontrib><creatorcontrib>Sankhyan, Naveen</creatorcontrib><creatorcontrib>Sripada, Kam</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choudhary, Anita</au><au>Gulati, Sheffali</au><au>Sagar, Rajesh</au><au>Sankhyan, Naveen</au><au>Sripada, Kam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Childhood epilepsy and ADHD comorbidity in an Indian tertiary medical center outpatient population</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-02-08</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>2670</spage><epage>7</epage><pages>2670-7</pages><artnum>2670</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>This study aimed to assess the prevalence of Attention Deficit Hyperactivity Disorder (ADHD) and its characteristics and risk factors in children with epilepsy at a tertiary medical center in New Delhi. Children with active epilepsy, aged 6 to 12 years, were assessed for ADHD using DSM-IV-TR criteria. Epilepsy and psychiatric characteristics, sociodemographic indicators, and use of antiepileptic drugs were analyzed for differences between the ADHD and non-ADHD groups. Among the 73 children with epilepsy, 23% (n = 17) had comorbid ADHD, of whom 59% (n = 10) had predominantly inattentive type, 35% (n = 6) combined type, and 6% (n = 1) predominantly hyperactive-impulsive type. Lower IQ scores, epileptiform EEG activity, not attending school, and male sex were significantly associated with comorbid ADHD in children with epilepsy. Groups were similar in terms of age, socioeconomic indicators, family history of psychiatric disorders, seizure frequency in the last six months, seizure etiology, and seizure type. Epilepsy is a common pediatric neurological condition with frequent psychiatric comorbidities, including ADHD. Specialists should collaborate to optimize treatment for children with epilepsy and ADHD, especially for families in developing countries where the burden of disease can be great.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29422636</pmid><doi>10.1038/s41598-018-20676-8</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/3187 692/617/375/178 692/617/375/366/1311 692/699/375/178 692/699/375/366/1311 Anticonvulsants - therapeutic use Antiepileptic agents Attention Deficit Disorder with Hyperactivity - physiopathology Attention Deficit Disorder with Hyperactivity - psychology Attention deficit hyperactivity disorder Child Childhood Children Cognition Disorders - complications Comorbidity Comorbidity - trends Convulsions & seizures Cross-Sectional Studies Developing countries EEG Epilepsy Epilepsy - complications Epilepsy - drug therapy Epilepsy - physiopathology Etiology Female Genetics Humanities and Social Sciences Humans Hyperactivity India - epidemiology LDCs Male Mental disorders multidisciplinary Outpatients Population studies Prevalence Psychiatric Status Rating Scales Retrospective Studies Risk factors Science Science (multidisciplinary) Seizures Seizures - drug therapy Severity of Illness Index |
| title | Childhood epilepsy and ADHD comorbidity in an Indian tertiary medical center outpatient population |
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