HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation

Despite significant advances in combinations of radiotherapy and chemotherapy, altered fractionation schedules and image-guided radiotherapy, many cancer patients fail to benefit from radiation. A prevailing hypothesis is that targeting repair of DNA double strand breaks (DSB) can enhance radiation...

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Veröffentlicht in:	Molecular cancer therapeutics 2018-02, Vol.17 (2), p.407-418
Hauptverfasser:	Efimova, Elena V, Ricco, Natalia, Labay, Edwardine, Mauceri, Helena J, Flor, Amy C, Ramamurthy, Aishwarya, Sutton, Harold G, Weichselbaum, Ralph R, Kron, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute effects Biosynthesis Cancer Cell death Cell proliferation Chemotherapy Cholesterol Deoxyribonucleic acid DNA DNA damage DNA repair Double-strand break repair Drug development Fractionation HMG-CoA reductase inhibitors Hydroxymethylglutaryl-CoA reductase Image enhancement Inhibition Inhibitors Ionizing radiation Irradiation Lipophilic Melanoma Patients Radiation effects Radiation therapy Radiosensitizers Repair Schedules Senescence Statins Toxicity Tumors
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