A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch

Chronic pain and itch are common hypersensitivity syndromes that are affected by endogenous mediators. We applied a systems-based, translational approach to predict, discover, and characterize mediators of pain and itch that are regulated by diet and inflammation. Profiling of tissue-specific precur...

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Veröffentlicht in:	Science signaling 2017-08, Vol.10 (493)
Hauptverfasser:	Ramsden, Christopher E, Domenichiello, Anthony F, Yuan, Zhi-Xin, Sapio, Matthew R, Keyes, Gregory S, Mishra, Santosh K, Gross, Jacklyn R, Majchrzak-Hong, Sharon, Zamora, Daisy, Horowitz, Mark S, Davis, John M, Sorokin, Alexander V, Dey, Amit, LaPaglia, Danielle M, Wheeler, Joshua J, Vasko, Michael R, Mehta, Nehal N, Mannes, Andrew J, Iadarola, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Calcitonin Calcitonin gene-related peptide Capsaicin Case-Control Studies Derivatives Diet Dietary intake Dorsal root ganglia Fatty acids Female Gene expression Headache Humans Hypersensitivity In Vitro Techniques Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Injection Ion channels Lesions Linoleic acid Linoleic Acid - chemistry Linoleic Acid - metabolism Male Mass spectrometry Mass spectroscopy Mice Middle Aged Nociceptors - metabolism Pain Pain - drug therapy Pain - metabolism Pain - pathology Pain perception Pain sensitivity Pharmacology Pruritus - drug therapy Pruritus - metabolism Pruritus - pathology Psoriasis - drug therapy Psoriasis - metabolism Psoriasis - pathology Rats Rats, Sprague-Dawley Receptors, Calcitonin Gene-Related Peptide - metabolism Rodents Scratching Scratching behavior Sensory Receptor Cells - cytology Sensory Receptor Cells - drug effects Sensory Receptor Cells - metabolism Skin Skin - cytology Skin - metabolism Skin - pathology Skin diseases Systems Analysis
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