Assembly of functionally integrated human forebrain spheroids

The development of the nervous system involves a coordinated succession of events including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons from ventral to dorsal forebrain and their integration into cortical circuits. However, these interregional interactions have not yet been mo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2017-05, Vol.545 (7652), p.54-59
Hauptverfasser:	Birey, Fikri, Andersen, Jimena, Makinson, Christopher D., Islam, Saiful, Wei, Wu, Huber, Nina, Fan, H. Christina, Metzler, Kimberly R. Cordes, Panagiotakos, Georgia, Thom, Nicholas, O’Rourke, Nancy A., Steinmetz, Lars M., Bernstein, Jonathan A., Hallmayer, Joachim, Huguenard, John R., Paşca, Sergiu P.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 14 38 631/378/2571 631/532/2182 Autistic Disorder - genetics Autistic Disorder - pathology Brain Calcium Calcium channels Calcium channels (voltage-gated) Cell Line Cell Movement Cells, Cultured Circuits Cortex Developmental biology Female Fetuses Forebrain GABAergic Neurons - cytology Glutamatergic transmission Glutamic Acid - metabolism Humanities and Social Sciences Humans In vitro methods and tests Integration Interneurons Interneurons - cytology Interneurons - pathology Long QT Syndrome - genetics Long QT Syndrome - pathology Male Models, Biological multidisciplinary Mutation Nervous system Neural circuitry Neurodevelopmental disorders Neurogenesis Neurons Neurons - cytology Neurons - pathology Physiological aspects Pluripotency Pluripotent Stem Cells - cytology Prosencephalon Prosencephalon - anatomy & histology Prosencephalon - cytology Prosencephalon - growth & development Science Spheroids Spheroids, Cellular - cytology Stem cells Synapses - physiology Syndactyly - genetics Syndactyly - pathology Three dimensional models γ-Aminobutyric acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!