Novel fluconazole derivatives with promising antifungal activity

[Display omitted] The fungistatic nature and toxicity concern associated with the azole drugs currently on the market have resulted in an increased demand for new azole antifungal agents for which these problematic characteristics do not exist. The extensive use of azoles has resulted in fungal stra...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2018-02, Vol.26 (3), p.573-580
Hauptverfasser:	Thamban Chandrika, Nishad, Shrestha, Sanjib K., Ngo, Huy X., Howard, Kaitlind C., Garneau-Tsodikova, Sylvie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - chemistry Antifungal Agents - pharmacology Antifungal Agents - toxicity Azoles Candida - drug effects Cell Line Cell Survival - drug effects Clinical isolates Cytotoxicity Drug Design Erythrocytes - cytology Erythrocytes - drug effects Erythrocytes - metabolism Fluconazole - chemistry Fluconazole - pharmacology Fluconazole - toxicity Fungi - drug effects Hemolysis Hemolysis - drug effects Mice Microbial Sensitivity Tests Structure-Activity Relationship Time-kill studies Voriconazole - pharmacology Voriconazole - toxicity
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