MicroRNAs and metastasis: small RNAs play big roles
MicroRNAs (miRNAs) are small non-coding RNAs regulating post-transcriptional gene expression. They play important roles in many biological processes under physiological or pathological conditions, including development, metabolism, tumorigenesis, metastasis, and immune response. Over the past 15 yea...
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| Veröffentlicht in: | Cancer and metastasis reviews 2018-03, Vol.37 (1), p.5-15 |
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| container_title | Cancer and metastasis reviews |
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| creator | Kim, Jongchan Yao, Fan Xiao, Zhenna Sun, Yutong Ma, Li |
| description | MicroRNAs (miRNAs) are small non-coding RNAs regulating post-transcriptional gene expression. They play important roles in many biological processes under physiological or pathological conditions, including development, metabolism, tumorigenesis, metastasis, and immune response. Over the past 15 years, significant insights have been gained into the roles of miRNAs in cancer. Depending on the cancer type, miRNAs can act as oncogenes, tumor suppressors, or metastasis regulators. In this review, we focus on the role of miRNAs as components of molecular networks regulating metastasis. These miRNAs, termed metastamiRs, promote or inhibit metastasis through various mechanisms, including regulation of migration, invasion, colonization, cancer stem cell properties, epithelial-mesenchymal transition, and microenvironment. Some of these metastamiRs represent attractive therapeutic targets for cancer treatment. |
| doi_str_mv | 10.1007/s10555-017-9712-y |
| format | Article |
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| subjects | Biomedical and Life Sciences Biomedicine Cancer Cancer Research Colonization Gene expression Genes Genetic aspects Genetic transcription Immune response Mesenchyme Metabolism Metastases Metastasis MicroRNA MicroRNAs miRNA Oncology Physiological aspects Post-transcription Stem cells Tumorigenesis |
| title | MicroRNAs and metastasis: small RNAs play big roles |
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