TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes

The Toll/interleukin-1 receptor (TIR) domain is the signature signaling domain of Toll-like receptors (TLRs) and their adaptors, serving as a scaffold for the assembly of protein complexes for innate immune signaling [1, 2]. TIR domain proteins are also expressed in plants, where they mediate diseas...

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Veröffentlicht in:	Current biology 2018-02, Vol.28 (3), p.421-430.e4
Hauptverfasser:	Essuman, Kow, Summers, Daniel W., Sasaki, Yo, Mao, Xianrong, Yim, Aldrin Kay Yuen, DiAntonio, Aaron, Milbrandt, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Archaea - enzymology Archaea - genetics Archaeal Proteins - genetics Archaeal Proteins - metabolism axon degeneration Axons - metabolism Bacteria - enzymology Bacteria - genetics Bacterial Proteins - genetics Bacterial Proteins - metabolism enzyme innate immunity Mice NAD SARM1 TIR Toll/interleukin-1 receptor domain
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