Effects of intrathecal bupivacaine on the NR2B/CaMKIIα/CREB signaling pathway in the rat lumbar spinal cord

Neuraxial anesthesia produces an anesthetic-sparing, sedative effect. The mechanism underlying this effect potentially involves decreased spinal afferent input. However, the neurochemical mechanisms at the spinal level remain unknown. The N‑methyl‑D‑aspartate receptor 2B subunit/calcium‑calmodulin‑d...

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Veröffentlicht in:	Molecular medicine reports 2018-01, Vol.17 (3), p.4508-4514
Hauptverfasser:	Zhao, Liyan, Zhang, Yonghai, Yang, Fan, Zhu, Di, Li, Ningkang, Zhao, Li, Li, Na, Yu, Jianqiang, Ma, Hanxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Arousal Bupivacaine Ca2+/calmodulin-dependent protein kinase II Calcium Calcium-binding protein Calmodulin Catheterization Cortex Cyclic AMP response element-binding protein Gene expression Glutamic acid receptors Immunohistochemistry Kinases N-Methyl-D-aspartic acid receptors Pain perception Polymerase chain reaction Reverse transcription Rodents Sensory neurons Signal transduction Spinal cord Studies Western blotting
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