Luteolin inhibits pancreatitis‑induced acinar‑ductal metaplasia, proliferation and epithelial‑mesenchymal transition of acinar cells

Luteolin, a flavone, has been demonstrated to have anti‑cancer properties. In the current study, the effects of luteolin on certain carcinogenesis‑associated changes induced by pancreatitis, which are significant risk factors for pancreatic cancer, were investigated. Male six‑week‑old C57BL6 mice us...

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Veröffentlicht in:	Molecular medicine reports 2018-03, Vol.17 (3), p.3681-3689
Hauptverfasser:	Huang, Xince, Bhugul, Pravin Avinash, Fan, Gang, Ye, Tingting, Huang, Shihao, Dai, Shengjie, Chen, Bicheng, Zhou, Mengtao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar cells Cadherins Carcinogenesis Cell proliferation Complications and side effects Cytokeratin E-cadherin Ectopic expression Epidermal growth factor receptors Flavonoids Gene expression Growth factors Health aspects Immunohistochemistry Inflammation Injection Kinases Laboratory animals Mesenchyme Metaplasia Metastasis Mortality Mutation N-Cadherin Pancreatic cancer Pancreatitis Peritoneum Phosphorylation Polymerase chain reaction Prevention Proteins Reverse transcription Risk factors Sox9 protein Stat3 protein Transcription factors Vimentin
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