Granulocytic myeloid‐derived suppressor cells (GR‐MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period
Summary Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri‐ or postnatal infections. Myeloid‐derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidenc...
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| Veröffentlicht in: | Clinical and experimental immunology 2018-03, Vol.191 (3), p.328-337 |
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| creator | Schwarz, J. Scheckenbach, V. Kugel, H. Spring, B. Pagel, J. Härtel, C. Pauluschke‐Fröhlich, J. Peter, A. Poets, C. F. Gille, C. Köstlin, N. |
| description | Summary
Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri‐ or postnatal infections. Myeloid‐derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR‐MDSC) play a pivotal role in mediating maternal–fetal tolerance. The role of MDSC for postnatal immune‐regulation in neonates is incompletely understood. Until the present time, nothing was known about expression of MDSC in preterm infants. In the present pilot study, we quantified GR‐MDSC counts in cord blood and peripheral blood of preterm infants born between 23 + 0 and 36 + 6 weeks of gestation (WOG) during the first 3 months of life and analysed the effect of perinatal infections. We show that GR‐MDSC are increased in cord blood independent of gestational age and remain elevated in peripheral blood of preterm infants during the neonatal period. After day 28 they drop to nearly adult levels. In case of perinatal or postnatal infection, GR‐MDSC accumulate further and correlate with inflammatory markers C‐reactive protein (CRP) and white blood cell counts (WBC). Our results point towards a role of GR‐MDSC for immune‐regulation in preterm infants and render them as a potential target for cell‐based therapy of infections in these patients.
In the present study we show that numbers of GR‐MDSC are increased in peripheral blood of preterm infants during the neonatal period and afterwards decline to adult levels. In case of perinatal infection, GR‐MDSC further accumulate and correlate with inflammatory markers. These results point towards a role of GR‐MDSC for immune‐regulation in preterm infants and render them to a potential target for cell‐based therapy of neonatal sepsis. |
| doi_str_mv | 10.1111/cei.13059 |
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Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri‐ or postnatal infections. Myeloid‐derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR‐MDSC) play a pivotal role in mediating maternal–fetal tolerance. The role of MDSC for postnatal immune‐regulation in neonates is incompletely understood. Until the present time, nothing was known about expression of MDSC in preterm infants. In the present pilot study, we quantified GR‐MDSC counts in cord blood and peripheral blood of preterm infants born between 23 + 0 and 36 + 6 weeks of gestation (WOG) during the first 3 months of life and analysed the effect of perinatal infections. We show that GR‐MDSC are increased in cord blood independent of gestational age and remain elevated in peripheral blood of preterm infants during the neonatal period. After day 28 they drop to nearly adult levels. In case of perinatal or postnatal infection, GR‐MDSC accumulate further and correlate with inflammatory markers C‐reactive protein (CRP) and white blood cell counts (WBC). Our results point towards a role of GR‐MDSC for immune‐regulation in preterm infants and render them as a potential target for cell‐based therapy of infections in these patients.
In the present study we show that numbers of GR‐MDSC are increased in peripheral blood of preterm infants during the neonatal period and afterwards decline to adult levels. In case of perinatal infection, GR‐MDSC further accumulate and correlate with inflammatory markers. These results point towards a role of GR‐MDSC for immune‐regulation in preterm infants and render them to a potential target for cell‐based therapy of neonatal sepsis.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1111/cei.13059</identifier><identifier>PMID: 28963753</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Blood ; C-reactive protein ; C-Reactive Protein - metabolism ; Complications ; Cord blood ; Female ; Fetal Blood - physiology ; Fetuses ; Flow Cytometry ; Gestation ; Gestational age ; Granulocytes - physiology ; Humans ; Immune Tolerance ; Immunological tolerance ; Immunotherapy, Adoptive - methods ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases - immunology ; Infant, Premature ; Infants ; infection ; Infection - immunology ; Infections ; Inflammation ; intra‐amniotic infection ; Male ; MDSC ; Morbidity ; Myeloid cells ; Myeloid-Derived Suppressor Cells - physiology ; Neonates ; Newborn babies ; Obstetric Labor, Premature - immunology ; Original ; Peripheral blood ; Postnatal infection ; Pregnancy ; Premature babies ; preterm infants ; sepsis ; Suppressor cells</subject><ispartof>Clinical and experimental immunology, 2018-03, Vol.191 (3), p.328-337</ispartof><rights>2017 British Society for Immunology</rights><rights>2017 British Society for Immunology.</rights><rights>2018 British Society for Immunology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4439-568309a40c66b09c44345a3f6bc6b169b0a025afef0cd41443026c6a87a0b17c3</citedby><cites>FETCH-LOGICAL-c4439-568309a40c66b09c44345a3f6bc6b169b0a025afef0cd41443026c6a87a0b17c3</cites><orcidid>0000-0003-3718-5507</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801499/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801499/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28963753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwarz, J.</creatorcontrib><creatorcontrib>Scheckenbach, V.</creatorcontrib><creatorcontrib>Kugel, H.</creatorcontrib><creatorcontrib>Spring, B.</creatorcontrib><creatorcontrib>Pagel, J.</creatorcontrib><creatorcontrib>Härtel, C.</creatorcontrib><creatorcontrib>Pauluschke‐Fröhlich, J.</creatorcontrib><creatorcontrib>Peter, A.</creatorcontrib><creatorcontrib>Poets, C. F.</creatorcontrib><creatorcontrib>Gille, C.</creatorcontrib><creatorcontrib>Köstlin, N.</creatorcontrib><title>Granulocytic myeloid‐derived suppressor cells (GR‐MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>Summary
Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri‐ or postnatal infections. Myeloid‐derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR‐MDSC) play a pivotal role in mediating maternal–fetal tolerance. The role of MDSC for postnatal immune‐regulation in neonates is incompletely understood. Until the present time, nothing was known about expression of MDSC in preterm infants. In the present pilot study, we quantified GR‐MDSC counts in cord blood and peripheral blood of preterm infants born between 23 + 0 and 36 + 6 weeks of gestation (WOG) during the first 3 months of life and analysed the effect of perinatal infections. We show that GR‐MDSC are increased in cord blood independent of gestational age and remain elevated in peripheral blood of preterm infants during the neonatal period. After day 28 they drop to nearly adult levels. In case of perinatal or postnatal infection, GR‐MDSC accumulate further and correlate with inflammatory markers C‐reactive protein (CRP) and white blood cell counts (WBC). Our results point towards a role of GR‐MDSC for immune‐regulation in preterm infants and render them as a potential target for cell‐based therapy of infections in these patients.
In the present study we show that numbers of GR‐MDSC are increased in peripheral blood of preterm infants during the neonatal period and afterwards decline to adult levels. In case of perinatal infection, GR‐MDSC further accumulate and correlate with inflammatory markers. These results point towards a role of GR‐MDSC for immune‐regulation in preterm infants and render them to a potential target for cell‐based therapy of neonatal sepsis.</description><subject>Adult</subject><subject>Blood</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Complications</subject><subject>Cord blood</subject><subject>Female</subject><subject>Fetal Blood - physiology</subject><subject>Fetuses</subject><subject>Flow Cytometry</subject><subject>Gestation</subject><subject>Gestational age</subject><subject>Granulocytes - physiology</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Immunological tolerance</subject><subject>Immunotherapy, Adoptive - methods</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Newborn, Diseases - immunology</subject><subject>Infant, Premature</subject><subject>Infants</subject><subject>infection</subject><subject>Infection - immunology</subject><subject>Infections</subject><subject>Inflammation</subject><subject>intra‐amniotic infection</subject><subject>Male</subject><subject>MDSC</subject><subject>Morbidity</subject><subject>Myeloid cells</subject><subject>Myeloid-Derived Suppressor Cells - physiology</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Obstetric Labor, Premature - immunology</subject><subject>Original</subject><subject>Peripheral blood</subject><subject>Postnatal infection</subject><subject>Pregnancy</subject><subject>Premature babies</subject><subject>preterm infants</subject><subject>sepsis</subject><subject>Suppressor cells</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9uFSEUxonR2NvqwhcwJG7axbQwMNxhY2Ku9dqkxsQ_a8LAmZaGgRFmrrk7H6ErH9AnkeutjZrIhsD3Ox_n8CH0jJJTWtaZAXdKGWnkA7SgTDRVXXP5EC0IIbKSlPADdJjzTTkKIerH6KBupWDLhi3Q93XSYfbRbCdn8LAFH5398e3WQnIbsDjP45gg55iwAe8zPl5_KPK71x9XJ1gbMw-z1xNgF7CJyeLOx2hx7HGpmiANReh1mDLWweIEgy4geNiUGovtnFy4wtM14AAx6El7PJaHo32CHvXaZ3h6tx-hz2_OP63eVpfv1xerV5eV4ZzJqhEtI1JzYoToiNxd8kazXnRGdFTIjmhSN7qHnhjLaZFJLYzQ7VKTji4NO0Iv977j3A1gDYQpaa_G5Aadtipqp_5WgrtWV3GjmpZQLmUxOL4zSPHLDHlSg8u7n9JlojkrKnlT02bJSEFf_IPexDmFMl6hJBctl0wU6mRPmRRzTtDfN0OJ2qWtStrqV9qFff5n9_fk73gLcLYHvjoP2_87qdX5xd7yJ5yJuBg</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Schwarz, J.</creator><creator>Scheckenbach, V.</creator><creator>Kugel, H.</creator><creator>Spring, B.</creator><creator>Pagel, J.</creator><creator>Härtel, C.</creator><creator>Pauluschke‐Fröhlich, J.</creator><creator>Peter, A.</creator><creator>Poets, C. F.</creator><creator>Gille, C.</creator><creator>Köstlin, N.</creator><general>Oxford University Press</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3718-5507</orcidid></search><sort><creationdate>201803</creationdate><title>Granulocytic myeloid‐derived suppressor cells (GR‐MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period</title><author>Schwarz, J. ; Scheckenbach, V. ; Kugel, H. ; Spring, B. ; Pagel, J. ; Härtel, C. ; Pauluschke‐Fröhlich, J. ; Peter, A. ; Poets, C. F. ; Gille, C. ; Köstlin, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4439-568309a40c66b09c44345a3f6bc6b169b0a025afef0cd41443026c6a87a0b17c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Blood</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Complications</topic><topic>Cord blood</topic><topic>Female</topic><topic>Fetal Blood - physiology</topic><topic>Fetuses</topic><topic>Flow Cytometry</topic><topic>Gestation</topic><topic>Gestational age</topic><topic>Granulocytes - physiology</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Immunological tolerance</topic><topic>Immunotherapy, Adoptive - methods</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Newborn, Diseases - immunology</topic><topic>Infant, Premature</topic><topic>Infants</topic><topic>infection</topic><topic>Infection - immunology</topic><topic>Infections</topic><topic>Inflammation</topic><topic>intra‐amniotic infection</topic><topic>Male</topic><topic>MDSC</topic><topic>Morbidity</topic><topic>Myeloid cells</topic><topic>Myeloid-Derived Suppressor Cells - physiology</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Obstetric Labor, Premature - immunology</topic><topic>Original</topic><topic>Peripheral blood</topic><topic>Postnatal infection</topic><topic>Pregnancy</topic><topic>Premature babies</topic><topic>preterm infants</topic><topic>sepsis</topic><topic>Suppressor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwarz, J.</creatorcontrib><creatorcontrib>Scheckenbach, V.</creatorcontrib><creatorcontrib>Kugel, H.</creatorcontrib><creatorcontrib>Spring, B.</creatorcontrib><creatorcontrib>Pagel, J.</creatorcontrib><creatorcontrib>Härtel, C.</creatorcontrib><creatorcontrib>Pauluschke‐Fröhlich, J.</creatorcontrib><creatorcontrib>Peter, A.</creatorcontrib><creatorcontrib>Poets, C. F.</creatorcontrib><creatorcontrib>Gille, C.</creatorcontrib><creatorcontrib>Köstlin, N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwarz, J.</au><au>Scheckenbach, V.</au><au>Kugel, H.</au><au>Spring, B.</au><au>Pagel, J.</au><au>Härtel, C.</au><au>Pauluschke‐Fröhlich, J.</au><au>Peter, A.</au><au>Poets, C. F.</au><au>Gille, C.</au><au>Köstlin, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granulocytic myeloid‐derived suppressor cells (GR‐MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>2018-03</date><risdate>2018</risdate><volume>191</volume><issue>3</issue><spage>328</spage><epage>337</epage><pages>328-337</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><abstract>Summary
Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri‐ or postnatal infections. Myeloid‐derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR‐MDSC) play a pivotal role in mediating maternal–fetal tolerance. The role of MDSC for postnatal immune‐regulation in neonates is incompletely understood. Until the present time, nothing was known about expression of MDSC in preterm infants. In the present pilot study, we quantified GR‐MDSC counts in cord blood and peripheral blood of preterm infants born between 23 + 0 and 36 + 6 weeks of gestation (WOG) during the first 3 months of life and analysed the effect of perinatal infections. We show that GR‐MDSC are increased in cord blood independent of gestational age and remain elevated in peripheral blood of preterm infants during the neonatal period. After day 28 they drop to nearly adult levels. In case of perinatal or postnatal infection, GR‐MDSC accumulate further and correlate with inflammatory markers C‐reactive protein (CRP) and white blood cell counts (WBC). Our results point towards a role of GR‐MDSC for immune‐regulation in preterm infants and render them as a potential target for cell‐based therapy of infections in these patients.
In the present study we show that numbers of GR‐MDSC are increased in peripheral blood of preterm infants during the neonatal period and afterwards decline to adult levels. In case of perinatal infection, GR‐MDSC further accumulate and correlate with inflammatory markers. These results point towards a role of GR‐MDSC for immune‐regulation in preterm infants and render them to a potential target for cell‐based therapy of neonatal sepsis.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28963753</pmid><doi>10.1111/cei.13059</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3718-5507</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Blood C-reactive protein C-Reactive Protein - metabolism Complications Cord blood Female Fetal Blood - physiology Fetuses Flow Cytometry Gestation Gestational age Granulocytes - physiology Humans Immune Tolerance Immunological tolerance Immunotherapy, Adoptive - methods Infant Infant, Newborn Infant, Newborn, Diseases - immunology Infant, Premature Infants infection Infection - immunology Infections Inflammation intra‐amniotic infection Male MDSC Morbidity Myeloid cells Myeloid-Derived Suppressor Cells - physiology Neonates Newborn babies Obstetric Labor, Premature - immunology Original Peripheral blood Postnatal infection Pregnancy Premature babies preterm infants sepsis Suppressor cells |
| title | Granulocytic myeloid‐derived suppressor cells (GR‐MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period |
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