Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity
Previous studies from our laboratory have shown that environmental enrichment (EE) in young rats results in improved learning ability and enhanced metabotropic glutamate receptor–dependent long-term potentiation (mGluR-dependent LTP) resulting from sustained activation of p70S6 kinase. Here, we inve...
Gespeichert in:
| Veröffentlicht in: | Neurobiology of aging 2018-03, Vol.63, p.1-11 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 11 |
|---|---|
| container_issue | |
| container_start_page | 1 |
| container_title | Neurobiology of aging |
| container_volume | 63 |
| creator | Cortese, Giuseppe P. Olin, Andrew O'Riordan, Kenneth Hullinger, Rikki Burger, Corinna |
| description | Previous studies from our laboratory have shown that environmental enrichment (EE) in young rats results in improved learning ability and enhanced metabotropic glutamate receptor–dependent long-term potentiation (mGluR-dependent LTP) resulting from sustained activation of p70S6 kinase. Here, we investigated whether 1-month EE is sufficient to improve hippocampus-dependent learning and memory and enhance hippocampal LTP in 23–24 month-old Fischer 344 male rats. Aged rats were housed in environmentally enriched, socially enriched, or standard housing conditions. We find that aged rats exposed to 1-month of EE demonstrate enhanced learning and memory relative to standard housed controls when tested in the Morris water maze and novel object recognition behavioral tasks. Furthermore, we find that environmentally enriched rats perform significantly better than socially enriched or standard housed rats in the radial-arm water maze and display enhanced mGluR5-dependent hippocampal LTP. Enhanced hippocampal function results from activity-dependent increases in the levels of mGluR5, Homer1c, and phospho-p70S6 kinase. These findings demonstrate that a short exposure of EE to aged rats can have significant effects on hippocampal function. |
| doi_str_mv | 10.1016/j.neurobiolaging.2017.11.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5801151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0197458017303731</els_id><sourcerecordid>1973454097</sourcerecordid><originalsourceid>FETCH-LOGICAL-c554t-97c193106a351548e86bc295fc866cdf3ecb363631264e83a9f20d47f9b830c03</originalsourceid><addsrcrecordid>eNqNUU1r3DAQFaWl2W7zF4oOPfQQuxpb8geUQgj5KCy0lOQsZHm8q8WWXMk27B_I746WTUNzKzqMRjPvzeg9Qj4DS4FB8XWfWpy9a4zr1dbYbZoxKFOAlDH-hqxAiCoBXpdvyYpBXSZcVOyMfAhhzxgreVm8J2dZnbEyK4sVeby2i_HODmgn1VO03ujdMaFmGL1bMNCdGUen1TDGejdbPRlnqbFUbbGlXk2BNocI3Cmr4zq0R-Xt8aJsSwccnD9c0M39r4vTw20__xbJnRvQg6Yqsi1mOnwk7zrVBzx_jmvycHN9f3WXbH7e_ri63CRaCD4ldamhzoEVKhcgeIVV0eisFp2uikK3XY66yYt4ICs4Vrmqu4y1vOzqpsqZZvmafD_xjnMzYKvjR73q5ejNoPxBOmXk64o1O7l1i4wiAgiIBF-eCbz7M2OY5GCCxr5XFt0cZFQ854KzGNbk26lVexeCx-5lDDB5tFLu5Wsr5dFKCSCjlRH-6d9VX8B_vYsNN6cGjIItBr0M2qDV2BqPepKtM_836Qm-47up</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1973454097</pqid></control><display><type>article</type><title>Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Cortese, Giuseppe P. ; Olin, Andrew ; O'Riordan, Kenneth ; Hullinger, Rikki ; Burger, Corinna</creator><creatorcontrib>Cortese, Giuseppe P. ; Olin, Andrew ; O'Riordan, Kenneth ; Hullinger, Rikki ; Burger, Corinna</creatorcontrib><description>Previous studies from our laboratory have shown that environmental enrichment (EE) in young rats results in improved learning ability and enhanced metabotropic glutamate receptor–dependent long-term potentiation (mGluR-dependent LTP) resulting from sustained activation of p70S6 kinase. Here, we investigated whether 1-month EE is sufficient to improve hippocampus-dependent learning and memory and enhance hippocampal LTP in 23–24 month-old Fischer 344 male rats. Aged rats were housed in environmentally enriched, socially enriched, or standard housing conditions. We find that aged rats exposed to 1-month of EE demonstrate enhanced learning and memory relative to standard housed controls when tested in the Morris water maze and novel object recognition behavioral tasks. Furthermore, we find that environmentally enriched rats perform significantly better than socially enriched or standard housed rats in the radial-arm water maze and display enhanced mGluR5-dependent hippocampal LTP. Enhanced hippocampal function results from activity-dependent increases in the levels of mGluR5, Homer1c, and phospho-p70S6 kinase. These findings demonstrate that a short exposure of EE to aged rats can have significant effects on hippocampal function.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2017.11.004</identifier><identifier>PMID: 29207276</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging - physiology ; Aging - psychology ; Animals ; Behavior, Animal - physiology ; Environment ; Environmental enrichment ; Hippocampus - physiology ; Homer Scaffolding Proteins - metabolism ; Homer1c ; Housing, Animal ; Learning - physiology ; Long-Term Potentiation - physiology ; LTP ; Male ; Maze Learning - physiology ; Memory - physiology ; mGluR ; Morris water maze ; p70S6 kinase ; Rats, Inbred F344 ; Receptor, Metabotropic Glutamate 5 - metabolism ; Receptors, Metabotropic Glutamate - physiology ; Recognition, Psychology - physiology ; Ribosomal Protein S6 Kinases, 70-kDa - metabolism ; Social enrichment ; Social Environment</subject><ispartof>Neurobiology of aging, 2018-03, Vol.63, p.1-11</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-97c193106a351548e86bc295fc866cdf3ecb363631264e83a9f20d47f9b830c03</citedby><cites>FETCH-LOGICAL-c554t-97c193106a351548e86bc295fc866cdf3ecb363631264e83a9f20d47f9b830c03</cites><orcidid>0000-0002-9432-0114</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2017.11.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29207276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cortese, Giuseppe P.</creatorcontrib><creatorcontrib>Olin, Andrew</creatorcontrib><creatorcontrib>O'Riordan, Kenneth</creatorcontrib><creatorcontrib>Hullinger, Rikki</creatorcontrib><creatorcontrib>Burger, Corinna</creatorcontrib><title>Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Previous studies from our laboratory have shown that environmental enrichment (EE) in young rats results in improved learning ability and enhanced metabotropic glutamate receptor–dependent long-term potentiation (mGluR-dependent LTP) resulting from sustained activation of p70S6 kinase. Here, we investigated whether 1-month EE is sufficient to improve hippocampus-dependent learning and memory and enhance hippocampal LTP in 23–24 month-old Fischer 344 male rats. Aged rats were housed in environmentally enriched, socially enriched, or standard housing conditions. We find that aged rats exposed to 1-month of EE demonstrate enhanced learning and memory relative to standard housed controls when tested in the Morris water maze and novel object recognition behavioral tasks. Furthermore, we find that environmentally enriched rats perform significantly better than socially enriched or standard housed rats in the radial-arm water maze and display enhanced mGluR5-dependent hippocampal LTP. Enhanced hippocampal function results from activity-dependent increases in the levels of mGluR5, Homer1c, and phospho-p70S6 kinase. These findings demonstrate that a short exposure of EE to aged rats can have significant effects on hippocampal function.</description><subject>Aging - physiology</subject><subject>Aging - psychology</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Environment</subject><subject>Environmental enrichment</subject><subject>Hippocampus - physiology</subject><subject>Homer Scaffolding Proteins - metabolism</subject><subject>Homer1c</subject><subject>Housing, Animal</subject><subject>Learning - physiology</subject><subject>Long-Term Potentiation - physiology</subject><subject>LTP</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Memory - physiology</subject><subject>mGluR</subject><subject>Morris water maze</subject><subject>p70S6 kinase</subject><subject>Rats, Inbred F344</subject><subject>Receptor, Metabotropic Glutamate 5 - metabolism</subject><subject>Receptors, Metabotropic Glutamate - physiology</subject><subject>Recognition, Psychology - physiology</subject><subject>Ribosomal Protein S6 Kinases, 70-kDa - metabolism</subject><subject>Social enrichment</subject><subject>Social Environment</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU1r3DAQFaWl2W7zF4oOPfQQuxpb8geUQgj5KCy0lOQsZHm8q8WWXMk27B_I746WTUNzKzqMRjPvzeg9Qj4DS4FB8XWfWpy9a4zr1dbYbZoxKFOAlDH-hqxAiCoBXpdvyYpBXSZcVOyMfAhhzxgreVm8J2dZnbEyK4sVeby2i_HODmgn1VO03ujdMaFmGL1bMNCdGUen1TDGejdbPRlnqbFUbbGlXk2BNocI3Cmr4zq0R-Xt8aJsSwccnD9c0M39r4vTw20__xbJnRvQg6Yqsi1mOnwk7zrVBzx_jmvycHN9f3WXbH7e_ri63CRaCD4ldamhzoEVKhcgeIVV0eisFp2uikK3XY66yYt4ICs4Vrmqu4y1vOzqpsqZZvmafD_xjnMzYKvjR73q5ejNoPxBOmXk64o1O7l1i4wiAgiIBF-eCbz7M2OY5GCCxr5XFt0cZFQ854KzGNbk26lVexeCx-5lDDB5tFLu5Wsr5dFKCSCjlRH-6d9VX8B_vYsNN6cGjIItBr0M2qDV2BqPepKtM_836Qm-47up</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Cortese, Giuseppe P.</creator><creator>Olin, Andrew</creator><creator>O'Riordan, Kenneth</creator><creator>Hullinger, Rikki</creator><creator>Burger, Corinna</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9432-0114</orcidid></search><sort><creationdate>20180301</creationdate><title>Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity</title><author>Cortese, Giuseppe P. ; Olin, Andrew ; O'Riordan, Kenneth ; Hullinger, Rikki ; Burger, Corinna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-97c193106a351548e86bc295fc866cdf3ecb363631264e83a9f20d47f9b830c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aging - physiology</topic><topic>Aging - psychology</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Environment</topic><topic>Environmental enrichment</topic><topic>Hippocampus - physiology</topic><topic>Homer Scaffolding Proteins - metabolism</topic><topic>Homer1c</topic><topic>Housing, Animal</topic><topic>Learning - physiology</topic><topic>Long-Term Potentiation - physiology</topic><topic>LTP</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Memory - physiology</topic><topic>mGluR</topic><topic>Morris water maze</topic><topic>p70S6 kinase</topic><topic>Rats, Inbred F344</topic><topic>Receptor, Metabotropic Glutamate 5 - metabolism</topic><topic>Receptors, Metabotropic Glutamate - physiology</topic><topic>Recognition, Psychology - physiology</topic><topic>Ribosomal Protein S6 Kinases, 70-kDa - metabolism</topic><topic>Social enrichment</topic><topic>Social Environment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cortese, Giuseppe P.</creatorcontrib><creatorcontrib>Olin, Andrew</creatorcontrib><creatorcontrib>O'Riordan, Kenneth</creatorcontrib><creatorcontrib>Hullinger, Rikki</creatorcontrib><creatorcontrib>Burger, Corinna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cortese, Giuseppe P.</au><au>Olin, Andrew</au><au>O'Riordan, Kenneth</au><au>Hullinger, Rikki</au><au>Burger, Corinna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>63</volume><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Previous studies from our laboratory have shown that environmental enrichment (EE) in young rats results in improved learning ability and enhanced metabotropic glutamate receptor–dependent long-term potentiation (mGluR-dependent LTP) resulting from sustained activation of p70S6 kinase. Here, we investigated whether 1-month EE is sufficient to improve hippocampus-dependent learning and memory and enhance hippocampal LTP in 23–24 month-old Fischer 344 male rats. Aged rats were housed in environmentally enriched, socially enriched, or standard housing conditions. We find that aged rats exposed to 1-month of EE demonstrate enhanced learning and memory relative to standard housed controls when tested in the Morris water maze and novel object recognition behavioral tasks. Furthermore, we find that environmentally enriched rats perform significantly better than socially enriched or standard housed rats in the radial-arm water maze and display enhanced mGluR5-dependent hippocampal LTP. Enhanced hippocampal function results from activity-dependent increases in the levels of mGluR5, Homer1c, and phospho-p70S6 kinase. These findings demonstrate that a short exposure of EE to aged rats can have significant effects on hippocampal function.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29207276</pmid><doi>10.1016/j.neurobiolaging.2017.11.004</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9432-0114</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 2018-03, Vol.63, p.1-11 |
| issn | 0197-4580 1558-1497 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5801151 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aging - physiology Aging - psychology Animals Behavior, Animal - physiology Environment Environmental enrichment Hippocampus - physiology Homer Scaffolding Proteins - metabolism Homer1c Housing, Animal Learning - physiology Long-Term Potentiation - physiology LTP Male Maze Learning - physiology Memory - physiology mGluR Morris water maze p70S6 kinase Rats, Inbred F344 Receptor, Metabotropic Glutamate 5 - metabolism Receptors, Metabotropic Glutamate - physiology Recognition, Psychology - physiology Ribosomal Protein S6 Kinases, 70-kDa - metabolism Social enrichment Social Environment |
| title | Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T00%3A29%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Environmental%20enrichment%20improves%20hippocampal%20function%20in%20aged%20rats%20by%20enhancing%20learning%20and%20memory,%20LTP,%20and%20mGluR5-Homer1c%20activity&rft.jtitle=Neurobiology%20of%20aging&rft.au=Cortese,%20Giuseppe%20P.&rft.date=2018-03-01&rft.volume=63&rft.spage=1&rft.epage=11&rft.pages=1-11&rft.issn=0197-4580&rft.eissn=1558-1497&rft_id=info:doi/10.1016/j.neurobiolaging.2017.11.004&rft_dat=%3Cproquest_pubme%3E1973454097%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1973454097&rft_id=info:pmid/29207276&rft_els_id=S0197458017303731&rfr_iscdi=true |