A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer

Numb functions as an oncosuppressor by inhibiting Notch signaling and stabilizing p53. This latter effect depends on the interaction of Numb with Mdm2, the E3 ligase that ubiquitinates p53 and commits it to degradation. In breast cancer (BC), loss of Numb results in a reduction of p53-mediated respo...

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Veröffentlicht in:	The Journal of cell biology 2018-02, Vol.217 (2), p.745-762
Hauptverfasser:	Colaluca, Ivan Nicola, Basile, Andrea, Freiburger, Lee, D'Uva, Veronica, Disalvatore, Davide, Vecchi, Manuela, Confalonieri, Stefano, Tosoni, Daniela, Cecatiello, Valentina, Malabarba, Maria Grazia, Yang, Chun-Jiun, Kainosho, Masatsune, Sattler, Michael, Mapelli, Marina, Pece, Salvatore, Di Fiore, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Line, Tumor Chemoresistance Degradation Female Fuzzy logic Genotoxicity Homeostasis Humans Isoforms MDM2 protein Membrane Proteins - genetics Membrane Proteins - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Notch protein NUMB protein p53 Protein Protein Isoforms - genetics Protein Isoforms - metabolism Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Signaling Splicing Stem cells Toxicity Tumor Suppressor Protein p53 - metabolism Tumors Ubiquitin-protein ligase
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