D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress

Cholestatic liver diseases are important causes of liver cirrhosis and liver transplantation, but few drugs are available for treatment. D-chiro-inositol （DCI）, an isomer of inositol found in many Leguminosae plants and in animal viscera, is used clinically for the treatment of polycystic ovary synd...

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Veröffentlicht in:	Acta pharmacologica Sinica 2018-02, Vol.39 (2), p.213-221
Hauptverfasser:	Zhao, Shuang-shuang, Li, Na-ren, Zhao, Wu-li, Liu, Hong, Ge, Mao-xu, Zhang, Yi-xuan, Zhao, Long-yin, You, Xue-fu, He, Hong-wei, Shao, Rong-guang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alanine Alanine transaminase Alanine Transaminase - blood Animal tissues Animals Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Aspartate aminotransferase Aspartate Aminotransferases - blood ATP Binding Cassette Transporter, Subfamily B, Member 11 - genetics ATP Binding Cassette Transporter, Subfamily B, Member 11 - metabolism ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Bile Bile Acids and Salts - metabolism Bile ducts Bile Ducts - surgery Biomedical and Life Sciences Biomedicine Cholestasis Cholestasis - prevention & control Cirrhosis Diabetes mellitus Disease Models, Animal Drinking water Fibrosis Gene Expression - drug effects Genomes Immunology Immunosuppressive agents Inositol Inositol - administration & dosage Inositol - therapeutic use Internal Medicine Ligation Liver Liver - pathology Liver cirrhosis Liver Cirrhosis - prevention & control Liver diseases Liver transplantation Male Medical Microbiology NF-kappa B - metabolism NF-κB protein Oligonucleotides Oral administration Original original-article Oxidation Oxidative stress Oxidative Stress - drug effects Pharmacology/Toxicology Polycystic ovary syndrome Protective Agents - administration & dosage Protective Agents - therapeutic use Rats Rats, Sprague-Dawley Rodents Secretion Serum levels Stereoisomerism Superoxide dismutase Superoxide Dismutase - metabolism Surgery Transplantation Vaccine Viscera 氧化应力胆汁酸分泌物老鼠稀释绑扎肝移植 DCl
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