SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models

Aberrant fibroblast growth factor receptor （FGFR） activation is found across a diverse spectrum of malignancies, especially those lacking effective treatments. SOMCL-085 is a novel FGFR-dominant multi-target kinase inhibitor. Here, we explored the FGFR- targeting anticancer activity of SOMCL-085 bot...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta pharmacologica Sinica 2018-02, Vol.39 (2), p.243-250
Hauptverfasser:	Jiang, Xi-fei, Dai, Yang, Peng, Xia, Shen, Yan-yan, Su, Yi, Wei, Man-man, Liu, Wei-ren, Ding, Zhen-bin, Zhang, Ao, Shi, Ying-hong, Ai, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Angiogenesis Animal models Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Biomedical and Life Sciences Biomedicine Cancer Cell Line, Tumor Cell lines Cell proliferation Enzyme inhibitors Extracellular signal-regulated kinase Female FGFR 有势力癌症指向模特儿显示 vivo 肿瘤生长 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 2 Fibroblast growth factor receptors G1 Phase Cell Cycle Checkpoints - drug effects Gastric cancer Humans Immunology Internal Medicine Kinases Lung cancer Medical Microbiology Mice Mice, Nude Naphthalenes - administration & dosage Naphthalenes - pharmacology Naphthalenes - therapeutic use Oral administration Original original-article Pharmacology/Toxicology Phosphorylation Piperazines - administration & dosage Piperazines - pharmacology Piperazines - therapeutic use Pyridines - administration & dosage Pyridines - pharmacology Pyridines - therapeutic use Receptors, Fibroblast Growth Factor - antagonists & inhibitors Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors Rodents S phase Signal Transduction - drug effects Tumor cell lines Tyrosine Vaccine Vascular endothelial growth factor receptors Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!