H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2

Infection of H5N1 influenza virus causes the highest mortality among all influenza viruses. The mechanisms underlying such high viral pathogenicity are incompletely understood. Here, we report that the H5N1 influenza virus encodes a microRNA-like small RNA, miR-HA-3p, which is processed from a stem...

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Veröffentlicht in:Cell research 2018-02, Vol.28 (2), p.157-171
Hauptverfasser: Li, Xihan, Fu, Zheng, Liang, Hongwei, Wang, Yanbo, Qi, Xian, Ding, Meng, Sun, Xinlei, Zhou, Zhen, Huang, Ying, Gu, Hongwei, Li, Limin, Chen, Xi, Li, Donghai, Zhao, Quan, Liu, Fenyong, Wang, Hua, Wang, Jin, Zen, Ke, Zhang, Chen-Yu
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Sprache:eng
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