Fibroblast-associated tumour microenvironment induces vascular structure-networked tumouroid

In vitro three-dimensional (3D) tumour models mimic natural cancer tissue in vivo , bridging the gap between conventional 2D in vitro testing and animal models. Stromal and cancer tissues with extracellular matrix (ECM) can provide a tumour microenvironment (TME) with cell-to-cell and cell-to-ECM in...

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Veröffentlicht in:	Scientific reports 2018-02, Vol.8 (1), p.2365-12, Article 2365
Hauptverfasser:	Lee, Sang Woo, Kwak, Hyeong Seob, Kang, Myoung-Hee, Park, Yun-Yong, Jeong, Gi Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/277 631/67/70 Angiogenesis Animal models Animals Cancer Cells, Cultured Drug resistance Drug screening Extracellular matrix Fibroblasts Fibroblasts - physiology Gene expression Humanities and Social Sciences Lung cancer Lung Neoplasms - physiopathology Metastases Metastasis Microfluidics Microfluidics - methods Models, Biological multidisciplinary Neovascularization, Physiologic Organ Culture Techniques - methods Science Science (multidisciplinary) Spheroids Stromal cells Stromal Cells - physiology Tumor Microenvironment Tumorigenesis Tumors
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