Recombinant fowlpox virus vector-based vaccines: expression kinetics, dissemination and safety profile following intranasal delivery

We have previously established that mucosal uptake of recombinant fowlpox virus (rFPV) vaccines is far superior to other vector-based vaccines. Specifically, intranasal priming with rFPV vaccines can recruit unique antigen-presenting cells, which induce excellent mucosal and systemic HIV-specific CD...

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Veröffentlicht in:	Journal of general virology 2017-03, Vol.98 (3), p.496-505
Hauptverfasser:	Townsend, David G, Trivedi, Shubhanshi, Jackson, Ronald J, Ranasinghe, Charani
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal AIDS Vaccines - administration & dosage AIDS Vaccines - adverse effects AIDS Vaccines - metabolism Animals Fowlpox virus Gastrointestinal Tract - metabolism Genetic Vectors - administration & dosage Genetic Vectors - adverse effects Green Fluorescent Proteins - analysis Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HIV Antigens - administration & dosage HIV Antigens - adverse effects HIV Antigens - metabolism Lentivirus Luminescent Proteins - analysis Luminescent Proteins - genetics Luminescent Proteins - metabolism Lung - metabolism Mice Mice, Inbred BALB C Molecular Imaging Nasal Mucosa - metabolism Poxviridae Red Fluorescent Protein Retroviridae Spleen - metabolism Vaccination Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology Vaccines, Synthetic - metabolism
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