Epithelial-derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection

Mucosal surfaces are under constant bombardment from potentially antigenic particles and so must maintain a balance between homeostasis and inappropriate immune activation and consequent pathology. Epithelial cells have a vital role orchestrating pulmonary homeostasis and defense against pathogens....

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Veröffentlicht in:	Mucosal immunology 2018-03, Vol.11 (2), p.523-535
Hauptverfasser:	Denney, L, Branchett, W, Gregory, L G, Oliver, R A, Lloyd, C M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127/1219 631/250/1933 631/250/255/1578 631/250/347 Allergology Animals Antibodies Biomedical and Life Sciences Biomedicine Cells, Cultured Gastroenterology Humans Immunity, Mucosal Immunology Influenza A virus - physiology Influenza, Human - immunology Interferon-beta - metabolism Lung - physiology Lung - virology Mice Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Infections - immunology Respiratory Mucosa - physiology Respiratory Mucosa - virology Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Virus Replication
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