The rolB plant oncogene affects multiple signaling protein modules related to hormone signaling and plant defense
The rolB plant oncogene of Agrobacterium rhizogenes perturbs many biochemical processes in transformed plant cells, thereby causing their neoplastic reprogramming. The oncogene renders the cells more tolerant to environmental stresses and herbicides and inhibits ROS elevation and programmed cell dea...
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| Veröffentlicht in: | Scientific reports 2018-02, Vol.8 (1), p.2285-14, Article 2285 |
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| creator | Bulgakov, Victor P. Vereshchagina, Yulia V. Bulgakov, Dmitry V. Veremeichik, Galina N. Shkryl, Yuri N. |
| description | The
rolB
plant oncogene of
Agrobacterium rhizogenes
perturbs many biochemical processes in transformed plant cells, thereby causing their neoplastic reprogramming. The oncogene renders the cells more tolerant to environmental stresses and herbicides and inhibits ROS elevation and programmed cell death. In the present work, we performed a proteomic analysis of
Arabidopsis thaliana rolB
-expressing callus line AtB-2, which represents a line with moderate expression of the oncogene. Our results show that under these conditions
rolB
greatly perturbs the expression of some chaperone-type proteins such as heat-shock proteins and cyclophilins. Heat-shock proteins of the DnaK subfamily were overexpressed in
rolB
-transformed calli, whereas the abundance of cyclophilins, members of the closely related single-domain cyclophilin family was decreased. Real-time PCR analysis of corresponding genes confirmed the reliability of proteomics data because gene expression correlated well with the expression of proteins. Bioinformatics analysis indicates that
rolB
can potentially affect several levels of signaling protein modules, including effector-triggered immunity (via the RPM1-RPS2 signaling module), the miRNA processing machinery, auxin and cytokinin signaling, the calcium signaling system and secondary metabolism. |
| doi_str_mv | 10.1038/s41598-018-20694-6 |
| format | Article |
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rolB
plant oncogene of
Agrobacterium rhizogenes
perturbs many biochemical processes in transformed plant cells, thereby causing their neoplastic reprogramming. The oncogene renders the cells more tolerant to environmental stresses and herbicides and inhibits ROS elevation and programmed cell death. In the present work, we performed a proteomic analysis of
Arabidopsis thaliana rolB
-expressing callus line AtB-2, which represents a line with moderate expression of the oncogene. Our results show that under these conditions
rolB
greatly perturbs the expression of some chaperone-type proteins such as heat-shock proteins and cyclophilins. Heat-shock proteins of the DnaK subfamily were overexpressed in
rolB
-transformed calli, whereas the abundance of cyclophilins, members of the closely related single-domain cyclophilin family was decreased. Real-time PCR analysis of corresponding genes confirmed the reliability of proteomics data because gene expression correlated well with the expression of proteins. Bioinformatics analysis indicates that
rolB
can potentially affect several levels of signaling protein modules, including effector-triggered immunity (via the RPM1-RPS2 signaling module), the miRNA processing machinery, auxin and cytokinin signaling, the calcium signaling system and secondary metabolism.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-20694-6</identifier><identifier>PMID: 29396465</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/106 ; 45/29 ; 45/77 ; 631/114 ; 631/449 ; 631/61 ; 82/58 ; 82/81 ; Agrobacterium - metabolism ; Apoptosis ; Arabidopsis - chemistry ; Arabidopsis - metabolism ; Arabidopsis - microbiology ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; beta-Glucosidase - genetics ; beta-Glucosidase - metabolism ; Bioinformatics ; Calcium signalling ; Callus ; Cell death ; Cells, Cultured ; DnaK protein ; Environmental stress ; Gene expression ; Gene Expression Profiling ; Heat shock proteins ; Herbicides ; Humanities and Social Sciences ; miRNA ; multidisciplinary ; Oncogenes ; Peptidylprolyl isomerase ; Plant cells ; Plant Cells - chemistry ; Plant Cells - metabolism ; Plant Diseases - microbiology ; Plant Growth Regulators - metabolism ; Plant Proteins - analysis ; Plant Proteins - genetics ; Proteins ; Proteome - analysis ; Proteomics ; Real-Time Polymerase Chain Reaction ; Science ; Science (multidisciplinary) ; Signal Transduction</subject><ispartof>Scientific reports, 2018-02, Vol.8 (1), p.2285-14, Article 2285</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-49813a429b85e4e6613eec0bc72664b360fd8a494d7905d820a47fb72e5495343</citedby><cites>FETCH-LOGICAL-c511t-49813a429b85e4e6613eec0bc72664b360fd8a494d7905d820a47fb72e5495343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797197/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797197/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27906,27907,41102,42171,51558,53773,53775</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29396465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bulgakov, Victor P.</creatorcontrib><creatorcontrib>Vereshchagina, Yulia V.</creatorcontrib><creatorcontrib>Bulgakov, Dmitry V.</creatorcontrib><creatorcontrib>Veremeichik, Galina N.</creatorcontrib><creatorcontrib>Shkryl, Yuri N.</creatorcontrib><title>The rolB plant oncogene affects multiple signaling protein modules related to hormone signaling and plant defense</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The
rolB
plant oncogene of
Agrobacterium rhizogenes
perturbs many biochemical processes in transformed plant cells, thereby causing their neoplastic reprogramming. The oncogene renders the cells more tolerant to environmental stresses and herbicides and inhibits ROS elevation and programmed cell death. In the present work, we performed a proteomic analysis of
Arabidopsis thaliana rolB
-expressing callus line AtB-2, which represents a line with moderate expression of the oncogene. Our results show that under these conditions
rolB
greatly perturbs the expression of some chaperone-type proteins such as heat-shock proteins and cyclophilins. Heat-shock proteins of the DnaK subfamily were overexpressed in
rolB
-transformed calli, whereas the abundance of cyclophilins, members of the closely related single-domain cyclophilin family was decreased. Real-time PCR analysis of corresponding genes confirmed the reliability of proteomics data because gene expression correlated well with the expression of proteins. Bioinformatics analysis indicates that
rolB
can potentially affect several levels of signaling protein modules, including effector-triggered immunity (via the RPM1-RPS2 signaling module), the miRNA processing machinery, auxin and cytokinin signaling, the calcium signaling system and secondary metabolism.</description><subject>13/106</subject><subject>45/29</subject><subject>45/77</subject><subject>631/114</subject><subject>631/449</subject><subject>631/61</subject><subject>82/58</subject><subject>82/81</subject><subject>Agrobacterium - metabolism</subject><subject>Apoptosis</subject><subject>Arabidopsis - chemistry</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis - microbiology</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>beta-Glucosidase - genetics</subject><subject>beta-Glucosidase - metabolism</subject><subject>Bioinformatics</subject><subject>Calcium signalling</subject><subject>Callus</subject><subject>Cell death</subject><subject>Cells, Cultured</subject><subject>DnaK protein</subject><subject>Environmental stress</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Heat shock proteins</subject><subject>Herbicides</subject><subject>Humanities and Social Sciences</subject><subject>miRNA</subject><subject>multidisciplinary</subject><subject>Oncogenes</subject><subject>Peptidylprolyl isomerase</subject><subject>Plant cells</subject><subject>Plant Cells - chemistry</subject><subject>Plant Cells - metabolism</subject><subject>Plant Diseases - microbiology</subject><subject>Plant Growth Regulators - metabolism</subject><subject>Plant Proteins - analysis</subject><subject>Plant Proteins - genetics</subject><subject>Proteins</subject><subject>Proteome - analysis</subject><subject>Proteomics</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Signal Transduction</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUtrFjEUhoMottT-ARcScONmNPdMNoIWb1BwU9chM3NmvimZZJpkhP57U-ezfApmcwLnOe-5vAi9pOQtJbx9lwWVpm0IbRtGlBGNeoLOGRGyYZyxpyf_M3SZ8y2pTzIjqHmOzpjhRgklz9HdzQFwiv4jXr0LBcfQxwkCYDeO0JeMl82XefWA8zwF5-cw4TXFAnPASxw2Dxkn8K7AgEvEh5iWGE5hF4aj9AAjhAwv0LPR-QyXx3iBfnz-dHP1tbn-_uXb1YfrppeUlkaYlnInmOlaCQKUohygJ12vmVKi44qMQ-uEEYM2RA4tI07osdMMpDCSC36B3u-669YtMPQQSnLermleXLq30c3270yYD3aKP63URlOjq8Cbo0CKdxvkYpc59-DrMhC3bKmpVzS6dq7o63_Q27ileoGdqkYp_TAR26k-xZwTjI_DUGIfTLW7qbaaan-balUtenW6xmPJHwsrwHcg11SYIJ30_r_sL94Yrmk</recordid><startdate>20180202</startdate><enddate>20180202</enddate><creator>Bulgakov, Victor P.</creator><creator>Vereshchagina, Yulia V.</creator><creator>Bulgakov, Dmitry V.</creator><creator>Veremeichik, Galina N.</creator><creator>Shkryl, Yuri N.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180202</creationdate><title>The rolB plant oncogene affects multiple signaling protein modules related to hormone signaling and plant defense</title><author>Bulgakov, Victor P. ; Vereshchagina, Yulia V. ; Bulgakov, Dmitry V. ; Veremeichik, Galina N. ; Shkryl, Yuri N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-49813a429b85e4e6613eec0bc72664b360fd8a494d7905d820a47fb72e5495343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>13/106</topic><topic>45/29</topic><topic>45/77</topic><topic>631/114</topic><topic>631/449</topic><topic>631/61</topic><topic>82/58</topic><topic>82/81</topic><topic>Agrobacterium - metabolism</topic><topic>Apoptosis</topic><topic>Arabidopsis - chemistry</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis - microbiology</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>beta-Glucosidase - genetics</topic><topic>beta-Glucosidase - metabolism</topic><topic>Bioinformatics</topic><topic>Calcium signalling</topic><topic>Callus</topic><topic>Cell death</topic><topic>Cells, Cultured</topic><topic>DnaK protein</topic><topic>Environmental stress</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Heat shock proteins</topic><topic>Herbicides</topic><topic>Humanities and Social Sciences</topic><topic>miRNA</topic><topic>multidisciplinary</topic><topic>Oncogenes</topic><topic>Peptidylprolyl isomerase</topic><topic>Plant cells</topic><topic>Plant Cells - chemistry</topic><topic>Plant Cells - metabolism</topic><topic>Plant Diseases - microbiology</topic><topic>Plant Growth Regulators - metabolism</topic><topic>Plant Proteins - analysis</topic><topic>Plant Proteins - genetics</topic><topic>Proteins</topic><topic>Proteome - analysis</topic><topic>Proteomics</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bulgakov, Victor P.</creatorcontrib><creatorcontrib>Vereshchagina, Yulia V.</creatorcontrib><creatorcontrib>Bulgakov, Dmitry V.</creatorcontrib><creatorcontrib>Veremeichik, Galina N.</creatorcontrib><creatorcontrib>Shkryl, Yuri N.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bulgakov, Victor P.</au><au>Vereshchagina, Yulia V.</au><au>Bulgakov, Dmitry V.</au><au>Veremeichik, Galina N.</au><au>Shkryl, Yuri N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The rolB plant oncogene affects multiple signaling protein modules related to hormone signaling and plant defense</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-02-02</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>2285</spage><epage>14</epage><pages>2285-14</pages><artnum>2285</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The
rolB
plant oncogene of
Agrobacterium rhizogenes
perturbs many biochemical processes in transformed plant cells, thereby causing their neoplastic reprogramming. The oncogene renders the cells more tolerant to environmental stresses and herbicides and inhibits ROS elevation and programmed cell death. In the present work, we performed a proteomic analysis of
Arabidopsis thaliana rolB
-expressing callus line AtB-2, which represents a line with moderate expression of the oncogene. Our results show that under these conditions
rolB
greatly perturbs the expression of some chaperone-type proteins such as heat-shock proteins and cyclophilins. Heat-shock proteins of the DnaK subfamily were overexpressed in
rolB
-transformed calli, whereas the abundance of cyclophilins, members of the closely related single-domain cyclophilin family was decreased. Real-time PCR analysis of corresponding genes confirmed the reliability of proteomics data because gene expression correlated well with the expression of proteins. Bioinformatics analysis indicates that
rolB
can potentially affect several levels of signaling protein modules, including effector-triggered immunity (via the RPM1-RPS2 signaling module), the miRNA processing machinery, auxin and cytokinin signaling, the calcium signaling system and secondary metabolism.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29396465</pmid><doi>10.1038/s41598-018-20694-6</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 13/106 45/29 45/77 631/114 631/449 631/61 82/58 82/81 Agrobacterium - metabolism Apoptosis Arabidopsis - chemistry Arabidopsis - metabolism Arabidopsis - microbiology Bacterial Proteins - genetics Bacterial Proteins - metabolism beta-Glucosidase - genetics beta-Glucosidase - metabolism Bioinformatics Calcium signalling Callus Cell death Cells, Cultured DnaK protein Environmental stress Gene expression Gene Expression Profiling Heat shock proteins Herbicides Humanities and Social Sciences miRNA multidisciplinary Oncogenes Peptidylprolyl isomerase Plant cells Plant Cells - chemistry Plant Cells - metabolism Plant Diseases - microbiology Plant Growth Regulators - metabolism Plant Proteins - analysis Plant Proteins - genetics Proteins Proteome - analysis Proteomics Real-Time Polymerase Chain Reaction Science Science (multidisciplinary) Signal Transduction |
| title | The rolB plant oncogene affects multiple signaling protein modules related to hormone signaling and plant defense |
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