Gene therapy for human glioblastoma using neurotropic JC virus-like particles as a gene delivery vector

Glioblastoma multiforme (GBM), the most common malignant brain tumor, has a short period of survival even with recent multimodality treatment. The neurotropic JC polyomavirus (JCPyV) infects glial cells and oligodendrocytes and causes fatal progressive multifocal leukoencephalopathy in patients with...

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Veröffentlicht in:	Scientific reports 2018-02, Vol.8 (1), p.2213-11, Article 2213
Hauptverfasser:	Chao, Chun-Nun, Yang, Yu-Hsuan, Wu, Mu-Sheng, Chou, Ming-Chieh, Fang, Chiung-Yao, Lin, Mien-Chun, Tai, Chien-Kuo, Shen, Cheng-Huang, Chen, Pei-Lain, Chang, Deching, Wang, Meilin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 14/19 42/109 42/41 42/44 631/67/1059/602 631/80 82/83 96 Acquired immune deficiency syndrome AIDS Animals Blood circulation Brain cancer Brain Neoplasms - therapy Brain tumors Cell Line, Tumor Drug Carriers Ganciclovir Gene therapy Gene transfer Genes, Reporter Genetic Therapy - methods Genetic Vectors Glial cells Glioblastoma Glioblastoma - therapy Green fluorescent protein Green Fluorescent Proteins - analysis Green Fluorescent Proteins - genetics Heterografts Humanities and Social Sciences Humans I.R. radiation JC Virus - genetics Kinases Leukoencephalopathy Metastases Mice, Nude multidisciplinary Neoplasm Transplantation Neuronal-glial interactions Oligodendrocytes Progressive multifocal leukoencephalopathy Reporter gene Rodents Science Science (multidisciplinary) Suicide Suicide genes Thymidine Thymidine kinase Transduction, Genetic Treatment Outcome Tumor cells Virosomes - genetics Virus-like particles Xenografts
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