Quantification of HSV-1-mediated expression of the ferritin MRI reporter in the mouse brain

The development of effective strategies for gene therapy has been hampered by difficulties verifying transgene delivery in vivo and quantifying gene expression non-invasively. Magnetic resonance imaging (MRI) offers high spatial resolution and three-dimensional views, without tissue depth limitation...

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Veröffentlicht in:	Gene therapy 2013-06, Vol.20 (6), p.589-596
Hauptverfasser:	Iordanova, B, Goins, W F, Clawson, D S, Hitchens, T K, Ahrens, E T
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/51/201 631/1647/2300/1514 631/208/199 Animals Biomedical and Life Sciences Biomedicine Brain Brain - diagnostic imaging Brain - metabolism Brain - pathology Brain mapping Cell Biology Central nervous system enabling-technologies Ferritin Ferritins - chemistry Ferritins - isolation & purification Ferritins - therapeutic use Gene Expression Gene Expression Regulation, Viral Gene mapping Gene Therapy Genes, Reporter Genetic aspects Genetic Therapy Health aspects Herpes simplex Herpes simplex virus Herpes simplex virus 1 Herpes viruses Herpesvirus 1, Human - genetics Herpesvirus 1, Human - isolation & purification Human Genetics Magnetic resonance imaging Magnetic Resonance Imaging - methods Mice Nanotechnology Neuroimaging NMR Nuclear magnetic resonance Proteins Protons Radiography Rodents Spatial discrimination
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