Conditions Inducing Excessive O-GlcNAcylation Inhibit BMP2-Induced Osteogenic Differentiation of C2C12 Cells

Hyperglycemic conditions in diabetic patients can affect various cellular functions, including the modulation of osteogenic differentiation. However, the molecular mechanisms by which hyperglycemia affects osteogenic differentiation are yet to be clarified. This study aimed to investigate whether th...

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Veröffentlicht in:	International journal of molecular sciences 2018-01, Vol.19 (1), p.202
Hauptverfasser:	Gu, Hanna, Song, Mina, Boonanantanasarn, Kanitsak, Baek, Kyunghwa, Woo, Kyung Mi, Ryoo, Hyun-Mo, Baek, Jeong-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Biocompatibility Bone growth Bone morphogenetic protein 2 Cbfa-1 protein Collagen (type I) Diabetes mellitus Differentiation (biology) Gene expression Glucosamine Glucose Glycosylation Hyperglycemia Molecular modelling N-Acetylglucosamine N-Acetylglucosaminidase O-GlcNAcylation Osteoblastogenesis Osteogenesis Phosphatase Proteins
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