The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation

Kaempferol, a flavonoid compound, is derived from the rhizome of ., which is used in traditional medicine in Asia. Autophagy has pleiotropic functions that are involved in cell growth, survival, nutrient supply under starvation, defense against pathogens, and antigen presentation. There are many stu...

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Veröffentlicht in:	International journal of molecular sciences 2018-01, Vol.19 (1), p.125
Hauptverfasser:	Kim, Chang-Ju, Shin, Sang-Hun, Kim, Bok-Joo, Kim, Chul-Hoon, Kim, Jung-Han, Kang, Hae-Mi, Park, Bong-Soo, Kim, In-Ryoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase Acid phosphatase (tartrate-resistant) Acid resistance Animals Antigen presentation Apoptosis Apoptosis - drug effects Apoptosis - genetics Autophagy Autophagy - drug effects Autophagy - genetics Biocompatibility Biomedical materials Bone resorption Bone Resorption - pathology Bone turnover Cell Differentiation - drug effects Cytotoxicity Flavonoids Gene Expression Regulation - drug effects Kaempferol Kaempferols - pharmacology Macrophages Metabolism Mice Osteoclastogenesis Osteoclasts - cytology Osteoclasts - drug effects Osteogenesis - drug effects Osteogenesis - genetics Osteoporosis Phagocytosis Proteolysis - drug effects RANK Ligand - pharmacology RAW 264.7 Cells Real time RNA, Messenger - genetics RNA, Messenger - metabolism Sequestosome-1 Protein - metabolism Starvation
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