Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways

Aquaporin-4 (AQP4) is the most abundant water channel in the brain, and its inhibition before inducing focal ischemia, using the AQP4 inhibitor TGN-020, has been showed to reduce oedema in imaging studies. Here, we aimed to evaluate, for the first time, the histopathological effects of a single dose...

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Veröffentlicht in:	International journal of molecular sciences 2017-12, Vol.19 (1), p.46
Hauptverfasser:	Pirici, Ionica, Balsanu, Tudor Adrian, Bogdan, Catalin, Margaritescu, Claudiu, Divan, Tamir, Vitalie, Vacaras, Mogoanta, Laurentiu, Pirici, Daniel, Carare, Roxana Octavia, Muresanu, Dafin Fior
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Albumins - metabolism Animals Antagonists Apoptosis Apoptosis - drug effects Aquaporin 4 Aquaporin 4 - antagonists & inhibitors Aquaporin 4 - metabolism Aquaporins Arteries - drug effects Arteries - pathology Basement membranes Blood vessels Brain - blood supply Brain - pathology Brain Ischemia - complications Brain Ischemia - drug therapy Brain Ischemia - pathology Brain Ischemia - physiopathology Caspase 3 - metabolism Cerebral blood flow Computational fluid dynamics Cytoplasm Disease Models, Animal Drainage Edema Edema - complications Edema - pathology Effusion Extravasation Extravasation of Diagnostic and Therapeutic Materials - complications Extravasation of Diagnostic and Therapeutic Materials - drug therapy Extravasation of Diagnostic and Therapeutic Materials - pathology Exudation Fluid flow Fractal analysis Glial fibrillary acidic protein Gliosis Gliosis - complications Gliosis - pathology Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Inhibitors Ischemia Motor Activity - drug effects Neuroimaging Niacinamide - analogs & derivatives Niacinamide - pharmacology Niacinamide - therapeutic use Parenchyma Reperfusion Stroke - complications Stroke - drug therapy Stroke - pathology Stroke - physiopathology Thiadiazoles - pharmacology Thiadiazoles - therapeutic use Treatment Outcome
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