Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction
The aim of the present study was to evaluate the clinical efficacy of platelet-rich fibrin (PRF) in preserving the alveolar ridge following human tooth extraction. A total of 28 patients were divided into two groups: The experimental and control groups (n=14 each). Following tooth extraction, the ex...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2018-03, Vol.15 (3), p.2277-2286 |
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| creator | Zhang, Yingdi Ruan, Zheng Shen, Minhua Tan, Luanjun Huang, Weiqin Wang, Lei Huang, Yuanliang |
| description | The aim of the present study was to evaluate the clinical efficacy of platelet-rich fibrin (PRF) in preserving the alveolar ridge following human tooth extraction. A total of 28 patients were divided into two groups: The experimental and control groups (n=14 each). Following tooth extraction, the experimental group was implanted with PRF membrane, whereas the control group was not. The gingival healing effect was assessed at 7 days, 1 and 3 months later. Cone-beam computed tomography was performed immediately and at 3 months following tooth extraction. The changes in alveolar ridge height, width, and bone mineral density were compared between the two groups. The alveolar bone was removed using the ring drill during the implant surgery at 3 months following tooth extraction. Histomorphometric evaluation was performed to compare new bone formation between groups. The patients in the experimental group reportedly felt better compared with the patients in the control group. The healing of gingival tissue was better in the experimental group than in the control group. A significantly greater novel bone area was observed in the PRF group compared with the control group (P |
| doi_str_mv | 10.3892/etm.2018.5696 |
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A total of 28 patients were divided into two groups: The experimental and control groups (n=14 each). Following tooth extraction, the experimental group was implanted with PRF membrane, whereas the control group was not. The gingival healing effect was assessed at 7 days, 1 and 3 months later. Cone-beam computed tomography was performed immediately and at 3 months following tooth extraction. The changes in alveolar ridge height, width, and bone mineral density were compared between the two groups. The alveolar bone was removed using the ring drill during the implant surgery at 3 months following tooth extraction. Histomorphometric evaluation was performed to compare new bone formation between groups. The patients in the experimental group reportedly felt better compared with the patients in the control group. The healing of gingival tissue was better in the experimental group than in the control group. A significantly greater novel bone area was observed in the PRF group compared with the control group (P<0.01). However, no statistically significant differences were observed in the mean value of buccal alveolar ridge height, lingual/palatal alveolar ridge height and alveolar ridge width between the two groups. These results suggested that PRF was advantageous in human alveolar ridge preservation with ease of use and simple handling. Histological analysis of novel bone formation confirmed that PRF increased the quality of the novel bone and enhanced the rate of bone formation, despite the effect of PRF was not significant to reduce alveolar bone resorption in the extraction socket alone.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2018.5696</identifier><identifier>PMID: 29456635</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Alveolar process ; Blood platelets ; Bone resorption ; Calcium phosphates ; Clinical medicine ; Complications and side effects ; Cytokines ; Dental implants ; Dental research ; Fibrin ; Fractures ; Growth factors ; Health aspects ; Methods ; Osteogenesis ; Patients ; Physiology ; Prevention ; Risk factors ; Studies ; Surgery ; Teeth ; Tooth extraction ; Tooth extractions ; Transplants & implants</subject><ispartof>Experimental and therapeutic medicine, 2018-03, Vol.15 (3), p.2277-2286</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright: © Zhang et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-e8fc092af443cd719c9fbc08cfcc5871cf3ccf69c36164b24fd9d1606e27cabb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795808/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795808/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29456635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yingdi</creatorcontrib><creatorcontrib>Ruan, Zheng</creatorcontrib><creatorcontrib>Shen, Minhua</creatorcontrib><creatorcontrib>Tan, Luanjun</creatorcontrib><creatorcontrib>Huang, Weiqin</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Huang, Yuanliang</creatorcontrib><title>Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>The aim of the present study was to evaluate the clinical efficacy of platelet-rich fibrin (PRF) in preserving the alveolar ridge following human tooth extraction. A total of 28 patients were divided into two groups: The experimental and control groups (n=14 each). Following tooth extraction, the experimental group was implanted with PRF membrane, whereas the control group was not. The gingival healing effect was assessed at 7 days, 1 and 3 months later. Cone-beam computed tomography was performed immediately and at 3 months following tooth extraction. The changes in alveolar ridge height, width, and bone mineral density were compared between the two groups. The alveolar bone was removed using the ring drill during the implant surgery at 3 months following tooth extraction. Histomorphometric evaluation was performed to compare new bone formation between groups. The patients in the experimental group reportedly felt better compared with the patients in the control group. The healing of gingival tissue was better in the experimental group than in the control group. A significantly greater novel bone area was observed in the PRF group compared with the control group (P<0.01). However, no statistically significant differences were observed in the mean value of buccal alveolar ridge height, lingual/palatal alveolar ridge height and alveolar ridge width between the two groups. These results suggested that PRF was advantageous in human alveolar ridge preservation with ease of use and simple handling. Histological analysis of novel bone formation confirmed that PRF increased the quality of the novel bone and enhanced the rate of bone formation, despite the effect of PRF was not significant to reduce alveolar bone resorption in the extraction socket alone.</description><subject>Alveolar process</subject><subject>Blood platelets</subject><subject>Bone resorption</subject><subject>Calcium phosphates</subject><subject>Clinical medicine</subject><subject>Complications and side effects</subject><subject>Cytokines</subject><subject>Dental implants</subject><subject>Dental research</subject><subject>Fibrin</subject><subject>Fractures</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Methods</subject><subject>Osteogenesis</subject><subject>Patients</subject><subject>Physiology</subject><subject>Prevention</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Surgery</subject><subject>Teeth</subject><subject>Tooth extraction</subject><subject>Tooth extractions</subject><subject>Transplants & implants</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptktFrFDEQxhdRbKl99FUCvviyZ5JNssmLUA6tQsEXfQ7Z2cldSm5zZnNn_e_N0mu1YvKQYfKbj5nha5rXjK46bfh7LLsVp0yvpDLqWXPOesNbRpl8foqp0eysuZznW1qPVExr-bI540ZIpTp53sR1DFMAFwl6j1BI8mQfXcGIpc0BtsSHIYeJpImULZJ9xhnz0ZVQE5Vdci4eMUWXSQ7jBolPMaafYdqQklLZErwr2cFS8Kp54V2c8fL0XjTfP338tv7c3ny9_rK-umlBaF5a1B6o4c4L0cHYMwPGD0A1eACpewa-A_DKQKeYEgMXfjQjU1Qh78ENQ3fRfLjX3R-GHY6AU-0g2n0OO5d_2eSCffozha3dpKOVvZGa6irw7iSQ048DzsXuwgwYo5swHWbLKRVCil4u6Nt_0Nt0yFMdr1JMdFxwZf5QGxfRhsmnZSeLqL2SHTem04pXavUfqt4RdwHShD7U_JOC9r4AcprnjP5xRkbt4hBbHbL0oe3ikMq_-Xsxj_SDH7rfYEq4eA</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Zhang, Yingdi</creator><creator>Ruan, Zheng</creator><creator>Shen, Minhua</creator><creator>Tan, Luanjun</creator><creator>Huang, Weiqin</creator><creator>Wang, Lei</creator><creator>Huang, Yuanliang</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180301</creationdate><title>Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction</title><author>Zhang, Yingdi ; Ruan, Zheng ; Shen, Minhua ; Tan, Luanjun ; Huang, Weiqin ; Wang, Lei ; Huang, Yuanliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-e8fc092af443cd719c9fbc08cfcc5871cf3ccf69c36164b24fd9d1606e27cabb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alveolar process</topic><topic>Blood platelets</topic><topic>Bone resorption</topic><topic>Calcium phosphates</topic><topic>Clinical medicine</topic><topic>Complications and side effects</topic><topic>Cytokines</topic><topic>Dental implants</topic><topic>Dental research</topic><topic>Fibrin</topic><topic>Fractures</topic><topic>Growth factors</topic><topic>Health aspects</topic><topic>Methods</topic><topic>Osteogenesis</topic><topic>Patients</topic><topic>Physiology</topic><topic>Prevention</topic><topic>Risk factors</topic><topic>Studies</topic><topic>Surgery</topic><topic>Teeth</topic><topic>Tooth extraction</topic><topic>Tooth extractions</topic><topic>Transplants & implants</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yingdi</creatorcontrib><creatorcontrib>Ruan, Zheng</creatorcontrib><creatorcontrib>Shen, Minhua</creatorcontrib><creatorcontrib>Tan, Luanjun</creatorcontrib><creatorcontrib>Huang, Weiqin</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Huang, Yuanliang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yingdi</au><au>Ruan, Zheng</au><au>Shen, Minhua</au><au>Tan, Luanjun</au><au>Huang, Weiqin</au><au>Wang, Lei</au><au>Huang, Yuanliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction</atitle><jtitle>Experimental and therapeutic medicine</jtitle><addtitle>Exp Ther Med</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>15</volume><issue>3</issue><spage>2277</spage><epage>2286</epage><pages>2277-2286</pages><issn>1792-0981</issn><eissn>1792-1015</eissn><abstract>The aim of the present study was to evaluate the clinical efficacy of platelet-rich fibrin (PRF) in preserving the alveolar ridge following human tooth extraction. A total of 28 patients were divided into two groups: The experimental and control groups (n=14 each). Following tooth extraction, the experimental group was implanted with PRF membrane, whereas the control group was not. The gingival healing effect was assessed at 7 days, 1 and 3 months later. Cone-beam computed tomography was performed immediately and at 3 months following tooth extraction. The changes in alveolar ridge height, width, and bone mineral density were compared between the two groups. The alveolar bone was removed using the ring drill during the implant surgery at 3 months following tooth extraction. Histomorphometric evaluation was performed to compare new bone formation between groups. The patients in the experimental group reportedly felt better compared with the patients in the control group. The healing of gingival tissue was better in the experimental group than in the control group. A significantly greater novel bone area was observed in the PRF group compared with the control group (P<0.01). However, no statistically significant differences were observed in the mean value of buccal alveolar ridge height, lingual/palatal alveolar ridge height and alveolar ridge width between the two groups. These results suggested that PRF was advantageous in human alveolar ridge preservation with ease of use and simple handling. Histological analysis of novel bone formation confirmed that PRF increased the quality of the novel bone and enhanced the rate of bone formation, despite the effect of PRF was not significant to reduce alveolar bone resorption in the extraction socket alone.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>29456635</pmid><doi>10.3892/etm.2018.5696</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alveolar process Blood platelets Bone resorption Calcium phosphates Clinical medicine Complications and side effects Cytokines Dental implants Dental research Fibrin Fractures Growth factors Health aspects Methods Osteogenesis Patients Physiology Prevention Risk factors Studies Surgery Teeth Tooth extraction Tooth extractions Transplants & implants |
| title | Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction |
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