Synergistic Anti-tumour Effects of Quercetin and Oncolytic Adenovirus expressing TRAIL in Human Hepatocellular Carcinoma
The combination of oncolytic adenoviruses and specific chemotherapy agents is fast emerging as a novel therapeutic approach for resistan the patocellular carcinoma (HCC) cells. A detailed analysis of the network between adenovirus and chemotherapeutic agents can help design an effective strategy to...
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| Veröffentlicht in: | Scientific reports 2018-02, Vol.8 (1), p.2182-8, Article 2182 |
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| creator | Zou, Hai Zheng, Yong-fa Ge, Wei Wang, Shi-bing Mou, Xiao-zhou |
| description | The combination of oncolytic adenoviruses and specific chemotherapy agents is fast emerging as a novel therapeutic approach for resistan the patocellular carcinoma (HCC) cells. A detailed analysis of the network between adenovirus and chemotherapeutic agents can help design an effective strategy to combat HCC. We sought to investigate whether a combined treatment of ZD55-TRAIL and quercetin can have an enhanced cell-killing effect on HCC cells.
In-vitro
experiments showed that quercetin can enhance ZD55-TRAIL mediated growth inhibition and apoptosis in HCC cells. In addition, we showed that quercetin reduced ZD55-TRAIL mediated NF-κB activation and down-regulated its downstream targets, which in turn promoted the pro-apoptotic action of ZD55-TRAIL. Furthermore,
in-vivo
experiments in mice injected with HuH-7 cells resulted in significantly greater reduction in tumour growth and volume following combined ZD55-TRAIL and quercetin treatment. In conclusion, we demonstrated that quercetin could sensitize human HCC cells to apoptosis via ZD55-TRAIL
in-vitro
and
in-vivo
and presented ZD55-TRAIL and quercetin combination as a suitable anti-HCC therapy. |
| doi_str_mv | 10.1038/s41598-018-20213-7 |
| format | Article |
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In-vitro
experiments showed that quercetin can enhance ZD55-TRAIL mediated growth inhibition and apoptosis in HCC cells. In addition, we showed that quercetin reduced ZD55-TRAIL mediated NF-κB activation and down-regulated its downstream targets, which in turn promoted the pro-apoptotic action of ZD55-TRAIL. Furthermore,
in-vivo
experiments in mice injected with HuH-7 cells resulted in significantly greater reduction in tumour growth and volume following combined ZD55-TRAIL and quercetin treatment. In conclusion, we demonstrated that quercetin could sensitize human HCC cells to apoptosis via ZD55-TRAIL
in-vitro
and
in-vivo
and presented ZD55-TRAIL and quercetin combination as a suitable anti-HCC therapy.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-20213-7</identifier><identifier>PMID: 29391509</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/1 ; 13/1 ; 13/2 ; 13/21 ; 14/1 ; 14/63 ; 631/326/596 ; 692/4028/67 ; 692/699/67 ; 82/80 ; Adenoviruses ; Animals ; Antioxidants - therapeutic use ; Apoptosis ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - therapy ; Cell Proliferation ; Chemotherapy ; Combined treatment ; Drug Combinations ; Growth inhibition ; Hepatocellular carcinoma ; Humanities and Social Sciences ; Humans ; Liver cancer ; Liver Neoplasms - pathology ; Liver Neoplasms - therapy ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; multidisciplinary ; NF-κB protein ; Oncolysis ; Oncolytic Virotherapy ; Quercetin ; Quercetin - therapeutic use ; Science ; Science (multidisciplinary) ; Signal Transduction ; Tumor Cells, Cultured ; Tumors ; Xenograft Model Antitumor Assays</subject><ispartof>Scientific reports, 2018-02, Vol.8 (1), p.2182-8, Article 2182</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-44c255471a0c453394525f3f785e5648ea0c30c6ec8a696acf4b0e1632f52ec83</citedby><cites>FETCH-LOGICAL-c474t-44c255471a0c453394525f3f785e5648ea0c30c6ec8a696acf4b0e1632f52ec83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794998/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794998/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29391509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zou, Hai</creatorcontrib><creatorcontrib>Zheng, Yong-fa</creatorcontrib><creatorcontrib>Ge, Wei</creatorcontrib><creatorcontrib>Wang, Shi-bing</creatorcontrib><creatorcontrib>Mou, Xiao-zhou</creatorcontrib><title>Synergistic Anti-tumour Effects of Quercetin and Oncolytic Adenovirus expressing TRAIL in Human Hepatocellular Carcinoma</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The combination of oncolytic adenoviruses and specific chemotherapy agents is fast emerging as a novel therapeutic approach for resistan the patocellular carcinoma (HCC) cells. A detailed analysis of the network between adenovirus and chemotherapeutic agents can help design an effective strategy to combat HCC. We sought to investigate whether a combined treatment of ZD55-TRAIL and quercetin can have an enhanced cell-killing effect on HCC cells.
In-vitro
experiments showed that quercetin can enhance ZD55-TRAIL mediated growth inhibition and apoptosis in HCC cells. In addition, we showed that quercetin reduced ZD55-TRAIL mediated NF-κB activation and down-regulated its downstream targets, which in turn promoted the pro-apoptotic action of ZD55-TRAIL. Furthermore,
in-vivo
experiments in mice injected with HuH-7 cells resulted in significantly greater reduction in tumour growth and volume following combined ZD55-TRAIL and quercetin treatment. In conclusion, we demonstrated that quercetin could sensitize human HCC cells to apoptosis via ZD55-TRAIL
in-vitro
and
in-vivo
and presented ZD55-TRAIL and quercetin combination as a suitable anti-HCC therapy.</description><subject>101/1</subject><subject>13/1</subject><subject>13/2</subject><subject>13/21</subject><subject>14/1</subject><subject>14/63</subject><subject>631/326/596</subject><subject>692/4028/67</subject><subject>692/699/67</subject><subject>82/80</subject><subject>Adenoviruses</subject><subject>Animals</subject><subject>Antioxidants - therapeutic use</subject><subject>Apoptosis</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Cell Proliferation</subject><subject>Chemotherapy</subject><subject>Combined treatment</subject><subject>Drug Combinations</subject><subject>Growth inhibition</subject><subject>Hepatocellular carcinoma</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - therapy</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>multidisciplinary</subject><subject>NF-κB protein</subject><subject>Oncolysis</subject><subject>Oncolytic Virotherapy</subject><subject>Quercetin</subject><subject>Quercetin - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zou, Hai</au><au>Zheng, Yong-fa</au><au>Ge, Wei</au><au>Wang, Shi-bing</au><au>Mou, Xiao-zhou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic Anti-tumour Effects of Quercetin and Oncolytic Adenovirus expressing TRAIL in Human Hepatocellular Carcinoma</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>2182</spage><epage>8</epage><pages>2182-8</pages><artnum>2182</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The combination of oncolytic adenoviruses and specific chemotherapy agents is fast emerging as a novel therapeutic approach for resistan the patocellular carcinoma (HCC) cells. A detailed analysis of the network between adenovirus and chemotherapeutic agents can help design an effective strategy to combat HCC. We sought to investigate whether a combined treatment of ZD55-TRAIL and quercetin can have an enhanced cell-killing effect on HCC cells.
In-vitro
experiments showed that quercetin can enhance ZD55-TRAIL mediated growth inhibition and apoptosis in HCC cells. In addition, we showed that quercetin reduced ZD55-TRAIL mediated NF-κB activation and down-regulated its downstream targets, which in turn promoted the pro-apoptotic action of ZD55-TRAIL. Furthermore,
in-vivo
experiments in mice injected with HuH-7 cells resulted in significantly greater reduction in tumour growth and volume following combined ZD55-TRAIL and quercetin treatment. In conclusion, we demonstrated that quercetin could sensitize human HCC cells to apoptosis via ZD55-TRAIL
in-vitro
and
in-vivo
and presented ZD55-TRAIL and quercetin combination as a suitable anti-HCC therapy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29391509</pmid><doi>10.1038/s41598-018-20213-7</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 101/1 13/1 13/2 13/21 14/1 14/63 631/326/596 692/4028/67 692/699/67 82/80 Adenoviruses Animals Antioxidants - therapeutic use Apoptosis Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Cell Proliferation Chemotherapy Combined treatment Drug Combinations Growth inhibition Hepatocellular carcinoma Humanities and Social Sciences Humans Liver cancer Liver Neoplasms - pathology Liver Neoplasms - therapy Male Mice Mice, Inbred BALB C Mice, Nude multidisciplinary NF-κB protein Oncolysis Oncolytic Virotherapy Quercetin Quercetin - therapeutic use Science Science (multidisciplinary) Signal Transduction Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays |
| title | Synergistic Anti-tumour Effects of Quercetin and Oncolytic Adenovirus expressing TRAIL in Human Hepatocellular Carcinoma |
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