Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation

Magnesium has been shown to effectively prevent vascular calcification associated with chronic kidney disease. Magnesium has been hypothesized to prevent the upregulation of osteoblastic genes that potentially drives calcification. However, extracellular effects of magnesium on hydroxyapatite format...

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Veröffentlicht in:	Scientific reports 2018-02, Vol.8 (1), p.2069-11, Article 2069
Hauptverfasser:	ter Braake, Anique D., Tinnemans, Paul T., Shanahan, Catherine M., Hoenderop, Joost G. J., de Baaij, Jeroen H. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/2 14 14/28 14/34 38 38/77 631/443 631/45 692/4019/592/2193 692/4022/1585/104/1586 Alkaline phosphatase Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals Apoptosis Boron Compounds - pharmacology Calcification Calcification (ectopic) Calcium phosphates Cattle Cells, Cultured Crystals Durapatite - metabolism Glycerophosphates - pharmacology Humanities and Social Sciences Hydroxyapatite Magnesium Magnesium - pharmacology multidisciplinary Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Osteoblasts Osteopontin Osteopontin - genetics Osteopontin - metabolism Phosphatase Science Science (multidisciplinary) Smooth muscle Spectroscopy Transcription Transient receptor potential proteins TRPM Cation Channels - antagonists & inhibitors Vascular Calcification - metabolism X-ray diffraction
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