Identification of Chemical Compounds That Inhibit the Function of Histidyl-tRNA Synthetase from Pseudomonas aeruginosa

Pseudomonas aeruginosa histidyl-tRNA synthetase (HisRS) was selected as a target for antibiotic drug development. The HisRS protein was overexpressed in Escherichia coli and kinetically evaluated. The KM values for interaction of HisRS with its three substrates, histidine, ATP, and tRNAHis, were 37....

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Veröffentlicht in:	SLAS discovery 2018-01, Vol.23 (1), p.65-75
Hauptverfasser:	Hu, Yanmei, Palmer, Stephanie O., Robles, Sara T., Resto, Tahyra, Dean, Frank B., Bullard, James M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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