Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing

Pancreatic neuroendocrine tumors (PNETs) are a genomically and clinically heterogeneous group of pancreatic neoplasms often diagnosed with distant metastases. Recurrent somatic mutations, chromosomal aberrations, and gene expression signatures in PNETs have been described, but the clinical significa...

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Veröffentlicht in:	Cold Spring Harbor molecular case studies 2018-02, Vol.4 (1), p.a002329
Hauptverfasser:	Wong, Hui-Li, Yang, Kevin C, Shen, Yaoqing, Zhao, Eric Y, Loree, Jonathan M, Kennecke, Hagen F, Kalloger, Steve E, Karasinska, Joanna M, Lim, Howard J, Mungall, Andrew J, Feng, Xiaolan, Davies, Janine M, Schrader, Kasmintan, Zhou, Chen, Karsan, Aly, Jones, Steven J M, Laskin, Janessa, Marra, Marco A, Schaeffer, David F, Gorski, Sharon M, Renouf, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Fatal Outcome Female Humans Male Middle Aged Neoplasm Metastasis Neuroendocrine Tumors - genetics Neuroendocrine Tumors - pathology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Research Report Transcriptome - genetics Treatment Outcome Whole Genome Sequencing
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