TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis
The T-box 19 (TBX19) gene encodes a transcription factor characterized by a highly conserved DNA-binding motif (T-box). Recent studies have revealed that TBX19 has been identified as one of the genes activated by KRAS mutations, and is upregulated in colon adenoma. These results indicate that TBX19...
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| Veröffentlicht in: | FUKUSHIMA JOURNAL OF MEDICAL SCIENCE 2017, Vol.63(3), pp.141-151 |
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| creator | Ando, Jin Saito, Motonobu Imai, Jun-ichi Ito, Emi Yanagisawa, Yuka Honma, Reiko Saito, Katsuharu Tachibana, Kazunoshin Momma, Tomoyuki Ohki, Shinji Ohtake, Tohru Watanabe, Shinya Waguri, Satoshi Kono, Koji Takenoshita, Seiichi |
| description | The T-box 19 (TBX19) gene encodes a transcription factor characterized by a highly conserved DNA-binding motif (T-box). Recent studies have revealed that TBX19 has been identified as one of the genes activated by KRAS mutations, and is upregulated in colon adenoma. These results indicate that TBX19 may work as an oncogene in colorectal cancer (CRC). However, the expression and role of TBX19 have yet to be investigated. Here, we investigated TBX19 mRNA and protein expressions in colon cancer cells or surgically resected CRC. We found that TBX19 mRNA expression was significantly increased in tumorous tissues compared to that in non-tumorous tissues, and increased TBX19 mRNA expression was associated with positive lymph node metastasis in our cohort. The expression of TBX19 mRNA was not correlated with that of TBX19 protein in tissue sample taken from the CRC patients. Moreover, TBX19 showed positive staining even in the normal colonic tissues and the adjacent non-tumorous tissues. These results suggest that the expression of TBX19 protein is not correlated with the expression of TBX19 mRNA. In addition, our results promote further investigations into the impact of TBX19 upregulation on colorectal carcinogenesis, as well as the underlying mechanisms. |
| doi_str_mv | 10.5387/fms.2017-08 |
| format | Article |
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Recent studies have revealed that TBX19 has been identified as one of the genes activated by KRAS mutations, and is upregulated in colon adenoma. These results indicate that TBX19 may work as an oncogene in colorectal cancer (CRC). However, the expression and role of TBX19 have yet to be investigated. Here, we investigated TBX19 mRNA and protein expressions in colon cancer cells or surgically resected CRC. We found that TBX19 mRNA expression was significantly increased in tumorous tissues compared to that in non-tumorous tissues, and increased TBX19 mRNA expression was associated with positive lymph node metastasis in our cohort. The expression of TBX19 mRNA was not correlated with that of TBX19 protein in tissue sample taken from the CRC patients. Moreover, TBX19 showed positive staining even in the normal colonic tissues and the adjacent non-tumorous tissues. These results suggest that the expression of TBX19 protein is not correlated with the expression of TBX19 mRNA. In addition, our results promote further investigations into the impact of TBX19 upregulation on colorectal carcinogenesis, as well as the underlying mechanisms.</description><identifier>ISSN: 0016-2590</identifier><identifier>EISSN: 2185-4610</identifier><identifier>DOI: 10.5387/fms.2017-08</identifier><identifier>PMID: 29199261</identifier><language>eng</language><publisher>Japan: THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE</publisher><subject>Adult ; Aged ; Cell Line, Tumor ; colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; cytoplasmic granular signal ; diagnostic biomarker ; Female ; Homeodomain Proteins - analysis ; Homeodomain Proteins - genetics ; Homeodomain Proteins - physiology ; Humans ; lymph node metastasis ; Lymphatic Metastasis ; Male ; Middle Aged ; Mutation ; Original ; Proto-Oncogene Proteins p21(ras) - genetics ; RNA, Messenger - analysis ; T-Box Domain Proteins - analysis ; T-Box Domain Proteins - genetics ; T-Box Domain Proteins - physiology ; TBX19</subject><ispartof>FUKUSHIMA JOURNAL OF MEDICAL SCIENCE, 2017, Vol.63(3), pp.141-151</ispartof><rights>2017 The Fukushima Society of Medical Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-766db1353725e59ce50213d711a483b9e0b95bf3e939b3d3f72146048753e3a3</citedby><cites>FETCH-LOGICAL-c573t-766db1353725e59ce50213d711a483b9e0b95bf3e939b3d3f72146048753e3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792498/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792498/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29199261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ando, Jin</creatorcontrib><creatorcontrib>Saito, Motonobu</creatorcontrib><creatorcontrib>Imai, Jun-ichi</creatorcontrib><creatorcontrib>Ito, Emi</creatorcontrib><creatorcontrib>Yanagisawa, Yuka</creatorcontrib><creatorcontrib>Honma, Reiko</creatorcontrib><creatorcontrib>Saito, Katsuharu</creatorcontrib><creatorcontrib>Tachibana, Kazunoshin</creatorcontrib><creatorcontrib>Momma, Tomoyuki</creatorcontrib><creatorcontrib>Ohki, Shinji</creatorcontrib><creatorcontrib>Ohtake, Tohru</creatorcontrib><creatorcontrib>Watanabe, Shinya</creatorcontrib><creatorcontrib>Waguri, Satoshi</creatorcontrib><creatorcontrib>Kono, Koji</creatorcontrib><creatorcontrib>Takenoshita, Seiichi</creatorcontrib><title>TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis</title><title>FUKUSHIMA JOURNAL OF MEDICAL SCIENCE</title><addtitle>Fukushima J. Med. Sci.</addtitle><description>The T-box 19 (TBX19) gene encodes a transcription factor characterized by a highly conserved DNA-binding motif (T-box). Recent studies have revealed that TBX19 has been identified as one of the genes activated by KRAS mutations, and is upregulated in colon adenoma. These results indicate that TBX19 may work as an oncogene in colorectal cancer (CRC). However, the expression and role of TBX19 have yet to be investigated. Here, we investigated TBX19 mRNA and protein expressions in colon cancer cells or surgically resected CRC. We found that TBX19 mRNA expression was significantly increased in tumorous tissues compared to that in non-tumorous tissues, and increased TBX19 mRNA expression was associated with positive lymph node metastasis in our cohort. The expression of TBX19 mRNA was not correlated with that of TBX19 protein in tissue sample taken from the CRC patients. Moreover, TBX19 showed positive staining even in the normal colonic tissues and the adjacent non-tumorous tissues. These results suggest that the expression of TBX19 protein is not correlated with the expression of TBX19 mRNA. In addition, our results promote further investigations into the impact of TBX19 upregulation on colorectal carcinogenesis, as well as the underlying mechanisms.</description><subject>Adult</subject><subject>Aged</subject><subject>Cell Line, Tumor</subject><subject>colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>cytoplasmic granular signal</subject><subject>diagnostic biomarker</subject><subject>Female</subject><subject>Homeodomain Proteins - analysis</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - physiology</subject><subject>Humans</subject><subject>lymph node metastasis</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Original</subject><subject>Proto-Oncogene Proteins p21(ras) - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>T-Box Domain Proteins - analysis</subject><subject>T-Box Domain Proteins - genetics</subject><subject>T-Box Domain Proteins - physiology</subject><subject>TBX19</subject><issn>0016-2590</issn><issn>2185-4610</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LwzAYgIMobk5P3iV36cxH0zQXYQ6_QPAywVtI07drRj9GUqf797ZuDoWQHN4nzwsPQpeUTAVP5U1RhykjVEYkPUJjRlMRxQklx2hMCE0iJhQZobMQVoTEShJyikZMUaVYQsfobXH3ThV2Abcb8PC19hAC5Ng12LZV68F2psLWNBY8Nk2OTQitdabrmU_Xlbja1usSN20OuIbOhP64cI5OClMFuNi_E7R4uF_Mn6KX18fn-ewlskLyLpJJkmeUCy6ZAKEsCMIozyWlJk55poBkSmQFB8VVxnNeSEbjhMSpFBy44RN0u9OuP7IacgtN502l197Vxm91a5z-P2lcqZftRgupWKzSXnC9E1jfhuChOPylRA9xdR9XD3E1Geirv-sO7G_NHpjtgFWfYQkHwPjO2Qp-ZAnXfLj20sPMlsZraPg3P7yN9Q</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Ando, Jin</creator><creator>Saito, Motonobu</creator><creator>Imai, Jun-ichi</creator><creator>Ito, Emi</creator><creator>Yanagisawa, Yuka</creator><creator>Honma, Reiko</creator><creator>Saito, Katsuharu</creator><creator>Tachibana, Kazunoshin</creator><creator>Momma, Tomoyuki</creator><creator>Ohki, Shinji</creator><creator>Ohtake, Tohru</creator><creator>Watanabe, Shinya</creator><creator>Waguri, Satoshi</creator><creator>Kono, Koji</creator><creator>Takenoshita, Seiichi</creator><general>THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE</general><general>The Fukushima Society of Medical Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis</title><author>Ando, Jin ; Saito, Motonobu ; Imai, Jun-ichi ; Ito, Emi ; Yanagisawa, Yuka ; Honma, Reiko ; Saito, Katsuharu ; Tachibana, Kazunoshin ; Momma, Tomoyuki ; Ohki, Shinji ; Ohtake, Tohru ; Watanabe, Shinya ; Waguri, Satoshi ; Kono, Koji ; Takenoshita, Seiichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-766db1353725e59ce50213d711a483b9e0b95bf3e939b3d3f72146048753e3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cell Line, Tumor</topic><topic>colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - pathology</topic><topic>cytoplasmic granular signal</topic><topic>diagnostic biomarker</topic><topic>Female</topic><topic>Homeodomain Proteins - analysis</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - physiology</topic><topic>Humans</topic><topic>lymph node metastasis</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Original</topic><topic>Proto-Oncogene Proteins p21(ras) - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>T-Box Domain Proteins - analysis</topic><topic>T-Box Domain Proteins - genetics</topic><topic>T-Box Domain Proteins - physiology</topic><topic>TBX19</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ando, Jin</creatorcontrib><creatorcontrib>Saito, Motonobu</creatorcontrib><creatorcontrib>Imai, Jun-ichi</creatorcontrib><creatorcontrib>Ito, Emi</creatorcontrib><creatorcontrib>Yanagisawa, Yuka</creatorcontrib><creatorcontrib>Honma, Reiko</creatorcontrib><creatorcontrib>Saito, Katsuharu</creatorcontrib><creatorcontrib>Tachibana, Kazunoshin</creatorcontrib><creatorcontrib>Momma, Tomoyuki</creatorcontrib><creatorcontrib>Ohki, Shinji</creatorcontrib><creatorcontrib>Ohtake, Tohru</creatorcontrib><creatorcontrib>Watanabe, Shinya</creatorcontrib><creatorcontrib>Waguri, Satoshi</creatorcontrib><creatorcontrib>Kono, Koji</creatorcontrib><creatorcontrib>Takenoshita, Seiichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>FUKUSHIMA JOURNAL OF MEDICAL SCIENCE</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ando, Jin</au><au>Saito, Motonobu</au><au>Imai, Jun-ichi</au><au>Ito, Emi</au><au>Yanagisawa, Yuka</au><au>Honma, Reiko</au><au>Saito, Katsuharu</au><au>Tachibana, Kazunoshin</au><au>Momma, Tomoyuki</au><au>Ohki, Shinji</au><au>Ohtake, Tohru</au><au>Watanabe, Shinya</au><au>Waguri, Satoshi</au><au>Kono, Koji</au><au>Takenoshita, Seiichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis</atitle><jtitle>FUKUSHIMA JOURNAL OF MEDICAL SCIENCE</jtitle><addtitle>Fukushima J. Med. Sci.</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>63</volume><issue>3</issue><spage>141</spage><epage>151</epage><pages>141-151</pages><issn>0016-2590</issn><eissn>2185-4610</eissn><abstract>The T-box 19 (TBX19) gene encodes a transcription factor characterized by a highly conserved DNA-binding motif (T-box). Recent studies have revealed that TBX19 has been identified as one of the genes activated by KRAS mutations, and is upregulated in colon adenoma. These results indicate that TBX19 may work as an oncogene in colorectal cancer (CRC). However, the expression and role of TBX19 have yet to be investigated. Here, we investigated TBX19 mRNA and protein expressions in colon cancer cells or surgically resected CRC. We found that TBX19 mRNA expression was significantly increased in tumorous tissues compared to that in non-tumorous tissues, and increased TBX19 mRNA expression was associated with positive lymph node metastasis in our cohort. The expression of TBX19 mRNA was not correlated with that of TBX19 protein in tissue sample taken from the CRC patients. Moreover, TBX19 showed positive staining even in the normal colonic tissues and the adjacent non-tumorous tissues. These results suggest that the expression of TBX19 protein is not correlated with the expression of TBX19 mRNA. In addition, our results promote further investigations into the impact of TBX19 upregulation on colorectal carcinogenesis, as well as the underlying mechanisms.</abstract><cop>Japan</cop><pub>THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE</pub><pmid>29199261</pmid><doi>10.5387/fms.2017-08</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Cell Line, Tumor colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology cytoplasmic granular signal diagnostic biomarker Female Homeodomain Proteins - analysis Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humans lymph node metastasis Lymphatic Metastasis Male Middle Aged Mutation Original Proto-Oncogene Proteins p21(ras) - genetics RNA, Messenger - analysis T-Box Domain Proteins - analysis T-Box Domain Proteins - genetics T-Box Domain Proteins - physiology TBX19 |
| title | TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis |
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