Manipulating the microbiome: evolution of a strategy to prevent S. aureus disease in children
Hospitalized infants have the highest rates of invasive Staphylococcus aureus disease of any population and infection control strategies such as decolonization have been insufficient. For decades, researchers began studying the microbiome in search of new prevention strategies. The resident microbio...
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| Veröffentlicht in: | Journal of perinatology 2018-02, Vol.38 (2), p.105-109 |
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| container_title | Journal of perinatology |
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| creator | Khamash, D F Voskertchian, A Milstone, A M |
| description | Hospitalized infants have the highest rates of invasive
Staphylococcus aureus
disease of any population and infection control strategies such as decolonization have been insufficient. For decades, researchers began studying the microbiome in search of new prevention strategies. The resident microbiota was found to be closely associated with susceptibility and at times, resistance to
S. aureus
colonization. The evolution of nucleic acid based techniques has enhanced our understanding of the complex relationship between the nasal microbiota and
S. aureus
colonization. We review what is known about bacterial communities in the nasal cavity of infants and discuss how future microbiome studies may help identify novel interventions to protect high-risk infants from
S. aureus
disease. |
| doi_str_mv | 10.1038/jp.2017.155 |
| format | Article |
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Staphylococcus aureus
disease of any population and infection control strategies such as decolonization have been insufficient. For decades, researchers began studying the microbiome in search of new prevention strategies. The resident microbiota was found to be closely associated with susceptibility and at times, resistance to
S. aureus
colonization. The evolution of nucleic acid based techniques has enhanced our understanding of the complex relationship between the nasal microbiota and
S. aureus
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S. aureus
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Staphylococcus aureus
disease of any population and infection control strategies such as decolonization have been insufficient. For decades, researchers began studying the microbiome in search of new prevention strategies. The resident microbiota was found to be closely associated with susceptibility and at times, resistance to
S. aureus
colonization. The evolution of nucleic acid based techniques has enhanced our understanding of the complex relationship between the nasal microbiota and
S. aureus
colonization. We review what is known about bacterial communities in the nasal cavity of infants and discuss how future microbiome studies may help identify novel interventions to protect high-risk infants from
S. aureus
disease.</description><subject>692/699/255/1318</subject><subject>692/700/1720</subject><subject>692/700/459/1748</subject><subject>Bacteria</subject><subject>Children</subject><subject>Colonization</subject><subject>Decolonization</subject><subject>Disease control</subject><subject>Evolution</subject><subject>Gram-positive bacteria</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Infants</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Nose</subject><subject>Nucleic acids</subject><subject>Pathogens</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Prevention</subject><subject>Risk factors</subject><subject>Risk groups</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus 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Staphylococcus aureus
disease of any population and infection control strategies such as decolonization have been insufficient. For decades, researchers began studying the microbiome in search of new prevention strategies. The resident microbiota was found to be closely associated with susceptibility and at times, resistance to
S. aureus
colonization. The evolution of nucleic acid based techniques has enhanced our understanding of the complex relationship between the nasal microbiota and
S. aureus
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S. aureus
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| ispartof | Journal of perinatology, 2018-02, Vol.38 (2), p.105-109 |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | 692/699/255/1318 692/700/1720 692/700/459/1748 Bacteria Children Colonization Decolonization Disease control Evolution Gram-positive bacteria Health aspects Health risks Infants Medicine Medicine & Public Health Microbiomes Microbiota Microbiota (Symbiotic organisms) Nose Nucleic acids Pathogens Pediatric Surgery Pediatrics Prevention Risk factors Risk groups Staphylococcus aureus Staphylococcus aureus infections state-of-the-art |
| title | Manipulating the microbiome: evolution of a strategy to prevent S. aureus disease in children |
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