PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

Preclinical evidence suggests that high-dose hypofractionated ionizing radiation (IR) can enhance anti-tumor immunity and result in significant tumor control when combined with immune checkpoint blockade (ICB). However, low-dose daily fractioned IR used for many tumor types including head and neck s...

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Veröffentlicht in:	Oncoimmunology 2018-03, Vol.7 (3), p.e1395996
Hauptverfasser:	Morisada, Megan, Clavijo, Paul E., Moore, Ellen, Sun, Lillian, Chamberlin, Michael, Van Waes, Carter, Hodge, James W., Mitchell, James B., Friedman, Jay, Allen, Clint T.
Format:	Artikel
Sprache:	eng
Schlagworte:	abscopal checkpoint immunity Original Research Radiation resistance
Online-Zugang:	Volltext
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