Artemether-Lumefantrine Versus Chloroquine for the Treatment of Uncomplicated Plasmodium knowlesi Malaria: An Open-Label Randomized Controlled Trial CAN KNOW

Plasmodium knowlesi is reported increasingly across Southeast Asia and is the most common cause of malaria in Malaysia. No randomized trials have assessed the comparative efficacy of artemether-lumefantrine (AL) for knowlesi malaria. A randomized controlled trial was conducted in 3 district hospital...

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Veröffentlicht in:	Clinical infectious diseases 2018-01, Vol.66 (2), p.229-236
Hauptverfasser:	Grigg, Matthew J, William, Timothy, Barber, Bridget E, Rajahram, Giri S, Menon, Jayaram, Schimann, Emma, Wilkes, Christopher S, Patel, Kaajal, Chandna, Arjun, Price, Ric N, Yeo, Tsin W, Anstey, Nicholas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged and Commentaries Anemia Antimalarials - administration & dosage Antimalarials - adverse effects Artemether Artemether, Lumefantrine Drug Combination - administration & dosage Artemether, Lumefantrine Drug Combination - adverse effects Artemisinin Child Child, Preschool Children Chloroquine Chloroquine - administration & dosage Chloroquine - adverse effects Clinical trials Confidence intervals Control methods Diagnostic systems Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - pathology Effectiveness Female Histidine Hospitals Humans Malaria Malaria - drug therapy Malaria - parasitology Malaysia Male Medical treatment Middle Aged Motivation Parasitemia Patients Plasmodium knowlesi Plasmodium knowlesi - isolation & purification Polymerase chain reaction Randomization Treatment Outcome Vector-borne diseases Young Adult
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Zusammenfassung:	Plasmodium knowlesi is reported increasingly across Southeast Asia and is the most common cause of malaria in Malaysia. No randomized trials have assessed the comparative efficacy of artemether-lumefantrine (AL) for knowlesi malaria. A randomized controlled trial was conducted in 3 district hospitals in Sabah, Malaysia to compare the efficacy of AL against chloroquine (CQ) for uncomplicated knowlesi malaria. Participants were included if they weighed >10 kg, had a parasitemia count
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/cix779