PfCDPK1 is critical for malaria parasite gametogenesis and mosquito infection

Efforts to knock out Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) from asexual erythrocytic stage have not been successful, indicating an indispensable role of the enzyme in asexual growth. We recently reported generation of a transgenic parasite with mutant CDPK1 [Bansal A, et...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-01, Vol.115 (4), p.774-779
Hauptverfasser:	Bansal, Abhisheka, Molina-Cruz, Alvaro, Brzostowski, Joseph, Liu, Poching, Luo, Yan, Gunalan, Karthigayan, Li, Yuesheng, Ribeiro, José M. C., Miller, Louis H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aquatic insects Biological Sciences Calcium Complementation CRISPR Gametogenesis Gene expression Genes Growth rate Infections Kinases Malaria Mosquitoes Mutation Parasites Plasmodium falciparum Protein kinase Ribonucleic acid RNA Schizonts Transcription Vector-borne diseases
Online-Zugang:	Volltext
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