Integrative genomic analysis of methylphenidate response in attention-deficit/hyperactivity disorder

Methylphenidate (MPH) is the most frequently used pharmacological treatment in children with attention-deficit/hyperactivity disorder (ADHD). However, a considerable interindividual variability exists in clinical outcome. Thus, we performed a genome-wide association study of MPH efficacy in 173 ADHD...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.1881-11, Article 1881
Hauptverfasser:	Pagerols, Mireia, Richarte, Vanesa, Sánchez-Mora, Cristina, Rovira, Paula, Soler Artigas, María, Garcia-Martínez, Iris, Calvo-Sánchez, Eva, Corrales, Montse, da Silva, Bruna Santos, Mota, Nina Roth, Victor, Marcelo Moraes, Rohde, Luis Augusto, Grevet, Eugenio Horacio, Bau, Claiton Henrique Dotto, Cormand, Bru, Casas, Miguel, Ramos-Quiroga, Josep Antoni, Ribasés, Marta
Format:	Artikel
Sprache:	eng
Schlagworte:	38/22 38/39 38/43 631/208/205/2138 631/378/2583 Adolescent Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - genetics Attention deficit disorder with hyperactivity in children Attention deficit hyperactivity disorder Attention-deficit-disordered children Central Nervous System Stimulants - therapeutic use Child Child, Preschool Children Drug therapy Female Gene mapping Genome-wide association studies Genome-Wide Association Study Genomes Genomic analysis Genomics - methods Genètica humana Human genetics Humanities and Social Sciences Humans Hyperactivity Male Methylphenidate Methylphenidate - therapeutic use Molecular modelling multidisciplinary Nervous system Neurological diseases Polymorphism, Single Nucleotide - drug effects Polymorphism, Single Nucleotide - genetics Quantitative trait loci Science Science (multidisciplinary) Single-nucleotide polymorphism Sistema nerviós Trastorns per dèficit d'atenció amb hiperactivitat en els infants Trastorns per dèficit d'atenció en els infants Treatment Outcome
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Zusammenfassung:	Methylphenidate (MPH) is the most frequently used pharmacological treatment in children with attention-deficit/hyperactivity disorder (ADHD). However, a considerable interindividual variability exists in clinical outcome. Thus, we performed a genome-wide association study of MPH efficacy in 173 ADHD paediatric patients. Although no variant reached genome-wide significance, the set of genes containing single-nucleotide polymorphisms (SNPs) nominally associated with MPH response (P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-018-20194-7