Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1

Hematopoietic stem cells (HSCs) mature from pre-HSCs that originate in the major arteries of the embryo. To identify HSCs from in vitro sources, it will be necessary to refine markers of HSCs matured ex vivo. We purified and compared the transcriptomes of pre-HSCs, HSCs matured ex vivo, and fetal li...

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Veröffentlicht in:	The Journal of experimental medicine 2018-02, Vol.215 (2), p.645-659
Hauptverfasser:	Tober, Joanna, Maijenburg, Marijke M W, Li, Yan, Gao, Long, Hadland, Brandon K, Gao, Peng, Minoura, Kodai, Bernstein, Irwin D, Tan, Kai, Speck, Nancy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Arteries Cell death Cell surface Embryogenesis Embryonic growth stage Equivalence Fetuses Gene expression Gene regulation Genes Hematopoietic stem cells Immune response Ligands Liver Maturation PD-L1 protein Signaling Stem cells Up-regulation
Online-Zugang:	Volltext
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