Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone

ABSTRACT Osteocytes sense loading in bone, but their mechanosensation mechanisms remain poorly understood. Plasma membrane disruptions (PMD) develop with loading under physiological conditions in many cell types (e.g., myocytes, endothelial cells). These PMD foster molecular flux across cell membran...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of orthopaedic research 2018-02, Vol.36 (2), p.653-662
Hauptverfasser:	Yu, Kanglun, Sellman, David P., Bahraini, Anoosh, Hagan, Mackenzie L., Elsherbini, Ahmed, Vanpelt, Kayce T., Marshall, Peyton L., Hamrick, Mark W., McNeil, Anna, McNeil, Paul L., McGee‐Lawrence, Meghan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Animals Apoptosis bone Bone and Bones - physiology Calcium - metabolism Cell Line cell wounding mechanical loading mechanotransduction Mechanotransduction, Cellular Mice Microfluidic Analytical Techniques osteocyte Osteocytes - physiology Primary Cell Culture skeleton Stress, Mechanical Weight-Bearing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!