Nutrient sensing in pancreatic islets: lessons from congenital hyperinsulinism and monogenic diabetes

Pancreatic beta cells sense changes in nutrients during the cycles of fasting and feeding and release insulin accordingly to maintain glucose homeostasis. Abnormal beta cell nutrient sensing resulting from gene mutations leads to hypoglycemia or diabetes. Glucokinase (GCK) plays a key role in beta c...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2018-01, Vol.1411 (1), p.65-82
Hauptverfasser:	Lu, Ming, Li, Changhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids beta cell Beta cells Calcium Calcium channels Calcium channels (voltage-gated) Chemoreception congenital hyperinsulinism Detection Diabetes Diabetes mellitus Genes Glucokinase Glucose Glutamate dehydrogenase Homeostasis Hypoglycemia Insulin Insulin secretion Ion channels monogenic diabetes Mutation Neonates Nutrient cycles Nutrient release Nutrients Pancreas Potassium Potassium channels (voltage-gated) Secretion
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