Regulated Alternative Splicing of Drosophila Dscam2 Is Necessary for Attaining the Appropriate Number of Photoreceptor Synapses

How the brain makes trillions of synaptic connections using a genome of only 20,000 genes is a major question in modern neuroscience. Alternative splicing is one mechanism that can increase the number of proteins produced by each gene, but its role in regulating synapse formation is poorly understoo...

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Veröffentlicht in:	Genetics (Austin) 2018-02, Vol.208 (2), p.717-728
Hauptverfasser:	Kerwin, Sarah K, Li, Joshua Shing Shun, Noakes, Peter G, Shin, Grace Ji-Eun, Millard, S Sean
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Animals, Genetically Modified Brain Dendrites Dendrites - metabolism Drosophila Drosophila Proteins - genetics Genetics Genomes Insects Investigations Isoforms Mutation Nervous system Neural Cell Adhesion Molecules - genetics Neurons Photoreceptor Cells, Invertebrate - metabolism Photoreceptor Cells, Invertebrate - ultrastructure Photoreceptors Protein Isoforms - genetics Proteins Splicing Synapses Synapses - metabolism Synaptogenesis
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