Tissue-Specific Gene Inactivation in Xenopus laevis : Knockout of lhx1 in the Kidney with CRISPR/Cas9

Studying genes involved in organogenesis is often difficult because many of these genes are also essential for early development. The allotetraploid frog, , is commonly used to study developmental processes, but because of the presence of two homeologs for many genes, it has been difficult to use as...

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Veröffentlicht in:	Genetics (Austin) 2018-02, Vol.208 (2), p.673-686
Hauptverfasser:	DeLay, Bridget D, Corkins, Mark E, Hanania, Hannah L, Salanga, Matthew, Deng, Jian Min, Sudou, Norihiro, Taira, Masanori, Horb, Marko E, Miller, Rachel K
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Albinism Amphibians Animals Antisense RNA CRISPR CRISPR-Cas Systems Deactivation Defects Design Drug screening Embryos Feasibility studies Gene Editing Gene expression Gene Knockout Techniques Gene Silencing Gene Targeting Genes Genetic engineering Genetic modification Genetics Genome editing Genomes Inactivation Investigations Kidney - metabolism Kidneys Laboratory animals LIM-Homeodomain Proteins - genetics Organ Specificity - genetics Organogenesis Phenotype Ribonucleic acid RNA RNA polymerase RNA, Guide, CRISPR-Cas Systems Rodents Transcription Factors - genetics Visualization Xenopus Xenopus laevis Xenopus laevis - genetics Xenopus Proteins - genetics
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