Gut Epithelial Vitamin D Receptor Regulates Microbiota-Dependent Mucosal Inflammation by Suppressing Intestinal Epithelial Cell Apoptosis

Abstract Recent studies show that colonic vitamin D receptor (VDR) signaling protects the mucosal epithelial barrier and suppresses colonic inflammation, but the underlying molecular mechanism remains to be fully understood. To investigate the implication of colonic VDR downregulation seen in patien...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2018-02, Vol.159 (2), p.967-979
Hauptverfasser:	He, Lei, Liu, Tianjing, Shi, Yongyan, Tian, Feng, Hu, Huiyuan, Deb, Dilip K, Chen, Yinyin, Bissonnette, Marc, Li, Yan Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Apoptosis Apoptosis - genetics Bacteria Calciferol Caspase inhibitors CD103 antigen CD11b antigen CDX2 protein Cell activation Clonal deletion Colitis Colitis - metabolism Colitis - microbiology Colitis - pathology Colon Colon - metabolism Colon - microbiology Colon - pathology Dendritic cells Depletion Digestive system Endocrinology Epithelial cells Epithelial Cells - microbiology Epithelial Cells - physiology Flox Gastrointestinal tract Helper cells Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - microbiology Inflammation - pathology Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Interferon Interleukin 17 Interleukins Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine Intestines - pathology Lymphocytes Lymphocytes T Membrane permeability Mice Mice, Transgenic Microbiota - physiology Mucosa Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism Receptors, Calcitriol - physiology Sexually transmitted diseases Signaling STD Vitamin D Vitamin D receptors γ-Interferon
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