Serotype prevalence and antibiotic susceptibility patterns of pneumococcal isolates in Zunyi city, China
To assess the serotype distribution and antimicrobial susceptibility of pneumococci isolated from inpatients of all ages suspected of having bacterial infections. In this retrospective study, pneumococcal isolates were consecutively collected from the Third Affiliated Hospital of Zunyi Medical Univ...
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| Veröffentlicht in: | Saudi medical journal 2017-12, Vol.38 (12), p.1243-1249 |
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| creator | Shen, Meijing Yao, Run Yue, Huan Zhang, Jingzhi Chen, Min Zhang, Weiwei Liu, Daishun Wu, Kaifeng |
| description | To assess the serotype distribution and antimicrobial susceptibility of pneumococci isolated from inpatients of all ages suspected of having bacterial infections.
In this retrospective study, pneumococcal isolates were consecutively collected from the Third Affiliated Hospital of Zunyi Medical University, in Zunyi city, China, between January 2014 and December 2016. Pneumococci were identified using routine microbiological assays. We performed antimicrobial susceptibility analyses using the bacteria identification/susceptibility system VITEK2 and E-tests. Capsular types of all isolates were determined by multiplex polymerase chain reaction.
We identified 778 pneumococcal isolates. Serotypes 19F, 6A/6B, 19A, 23F, and 15B/15C were the most prevalent strains, accounting for 71.5% (556/778) of all isolates. Data show that 409 (70.4%) isolates could be covered by the PCV13 vaccine in children less than 2 years old. Irrespective of serotypes, 747 (96%) isolates were sensitive to penicillin, while 720 to 778 (90% to 100%) isolates were not susceptible to erythromycin, tetracycline, and trimethoprim/sulfamethoxazole. For isolates resistant to penicillin, ceftriaxone, cefotaxime, and meropenem, 22 to 39 (70% to 81.25%) strains belonged to PCV13 serotypes.
We found a substantial increase in the annual number of pneumococcal isolates since 2014. The theoretical impact of PCV13 was high in children less than 2 years old, and penicillin might be effective against pneumococcal infections in this region. |
| doi_str_mv | 10.15537/smj.2017.12.21090 |
| format | Article |
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In this retrospective study, pneumococcal isolates were consecutively collected from the Third Affiliated Hospital of Zunyi Medical University, in Zunyi city, China, between January 2014 and December 2016. Pneumococci were identified using routine microbiological assays. We performed antimicrobial susceptibility analyses using the bacteria identification/susceptibility system VITEK2 and E-tests. Capsular types of all isolates were determined by multiplex polymerase chain reaction.
We identified 778 pneumococcal isolates. Serotypes 19F, 6A/6B, 19A, 23F, and 15B/15C were the most prevalent strains, accounting for 71.5% (556/778) of all isolates. Data show that 409 (70.4%) isolates could be covered by the PCV13 vaccine in children less than 2 years old. Irrespective of serotypes, 747 (96%) isolates were sensitive to penicillin, while 720 to 778 (90% to 100%) isolates were not susceptible to erythromycin, tetracycline, and trimethoprim/sulfamethoxazole. For isolates resistant to penicillin, ceftriaxone, cefotaxime, and meropenem, 22 to 39 (70% to 81.25%) strains belonged to PCV13 serotypes.
We found a substantial increase in the annual number of pneumococcal isolates since 2014. The theoretical impact of PCV13 was high in children less than 2 years old, and penicillin might be effective against pneumococcal infections in this region.</description><identifier>ISSN: 0379-5284</identifier><identifier>EISSN: 1658-3175</identifier><identifier>DOI: 10.15537/smj.2017.12.21090</identifier><identifier>PMID: 29209675</identifier><language>eng</language><publisher>Saudi Arabia: Saudi Medical Journal</publisher><subject>Age groups ; Analysis ; Antibiotics ; Antimicrobial agents ; Bacterial infections ; Epidemiology ; FDA approval ; Microbial drug resistance ; Original ; Pediatrics ; Penicillin ; Polymerase chain reaction ; Preschool children ; Prevalence studies (Epidemiology) ; Statistical analysis ; Streptococcus infections ; Streptococcus pneumoniae ; Vaccines</subject><ispartof>Saudi medical journal, 2017-12, Vol.38 (12), p.1243-1249</ispartof><rights>COPYRIGHT 2017 Saudi Medical Journal</rights><rights>Saudi Medical Journal 2017. This work is licensed under the Creative Commons Attribution – Non-Commercial – Share Alike License http://creativecommons.org/licenses/by-nc-sa/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © Saudi Medical Journal 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-7831725e556d13d34f88f263a0bd64e2af80f2270a0146acbc59f02b7b6cf35d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787637/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787637/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29209675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Meijing</creatorcontrib><creatorcontrib>Yao, Run</creatorcontrib><creatorcontrib>Yue, Huan</creatorcontrib><creatorcontrib>Zhang, Jingzhi</creatorcontrib><creatorcontrib>Chen, Min</creatorcontrib><creatorcontrib>Zhang, Weiwei</creatorcontrib><creatorcontrib>Liu, Daishun</creatorcontrib><creatorcontrib>Wu, Kaifeng</creatorcontrib><title>Serotype prevalence and antibiotic susceptibility patterns of pneumococcal isolates in Zunyi city, China</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>To assess the serotype distribution and antimicrobial susceptibility of pneumococci isolated from inpatients of all ages suspected of having bacterial infections.
In this retrospective study, pneumococcal isolates were consecutively collected from the Third Affiliated Hospital of Zunyi Medical University, in Zunyi city, China, between January 2014 and December 2016. Pneumococci were identified using routine microbiological assays. We performed antimicrobial susceptibility analyses using the bacteria identification/susceptibility system VITEK2 and E-tests. Capsular types of all isolates were determined by multiplex polymerase chain reaction.
We identified 778 pneumococcal isolates. Serotypes 19F, 6A/6B, 19A, 23F, and 15B/15C were the most prevalent strains, accounting for 71.5% (556/778) of all isolates. Data show that 409 (70.4%) isolates could be covered by the PCV13 vaccine in children less than 2 years old. Irrespective of serotypes, 747 (96%) isolates were sensitive to penicillin, while 720 to 778 (90% to 100%) isolates were not susceptible to erythromycin, tetracycline, and trimethoprim/sulfamethoxazole. For isolates resistant to penicillin, ceftriaxone, cefotaxime, and meropenem, 22 to 39 (70% to 81.25%) strains belonged to PCV13 serotypes.
We found a substantial increase in the annual number of pneumococcal isolates since 2014. The theoretical impact of PCV13 was high in children less than 2 years old, and penicillin might be effective against pneumococcal infections in this region.</description><subject>Age groups</subject><subject>Analysis</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Bacterial infections</subject><subject>Epidemiology</subject><subject>FDA approval</subject><subject>Microbial drug resistance</subject><subject>Original</subject><subject>Pediatrics</subject><subject>Penicillin</subject><subject>Polymerase chain reaction</subject><subject>Preschool children</subject><subject>Prevalence studies (Epidemiology)</subject><subject>Statistical analysis</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae</subject><subject>Vaccines</subject><issn>0379-5284</issn><issn>1658-3175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUk9vFSEcJEZjn9Uv4MGQeOmhu_Jngd2LSfNi1aSJB_XihbDsjz5edmGF3Sbv28tra7XGEEKAmYGZDEKvKampEFy9y9O-ZoSqmrKaUdKRJ2hDpWgrTpV4ijaEq64SrG1O0Iuc94RwKYl8jk5Yx0gnldig3VdIcTnMgOcEN2aEYAGbMJS5-N7HxVuc12xhPm5HvxzwbJYFUsg4OjwHWKdoo7VmxD7H0SyQsQ_4xxoOHtuCP8fbnQ_mJXrmzJjh1f16ir5ffvi2_VRdffn4eXtxVdlG8KVSbfk7EyCEHCgfeOPa1jHJDekH2QAzriWOMUUMoY00treic4T1qpfWcTHwU_T-Tnde-wkGC2FJZtRz8pNJBx2N149vgt_p63ijhWqV5KoInN0LpPhzhbzoyRf_42gCxDVr2ineSNJRUaBv_4Hu45pCsacZKxkrIUTzB3Vd4tU-uFjetUdRfSGY4qxrKS2o-j-oMgaYvI0BnC_njwjsjmBTzDmBe_BIib7thy790Md-aMr0bT8K6c3f6TxQfheC_wKE1rd0</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Shen, Meijing</creator><creator>Yao, Run</creator><creator>Yue, Huan</creator><creator>Zhang, Jingzhi</creator><creator>Chen, Min</creator><creator>Zhang, Weiwei</creator><creator>Liu, Daishun</creator><creator>Wu, Kaifeng</creator><general>Saudi Medical Journal</general><general>Prince Sultan Military Medical City (PSMMC)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201712</creationdate><title>Serotype prevalence and antibiotic susceptibility patterns of pneumococcal isolates in Zunyi city, China</title><author>Shen, Meijing ; Yao, Run ; Yue, Huan ; Zhang, Jingzhi ; Chen, Min ; Zhang, Weiwei ; Liu, Daishun ; Wu, Kaifeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-7831725e556d13d34f88f263a0bd64e2af80f2270a0146acbc59f02b7b6cf35d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age groups</topic><topic>Analysis</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Bacterial infections</topic><topic>Epidemiology</topic><topic>FDA approval</topic><topic>Microbial drug resistance</topic><topic>Original</topic><topic>Pediatrics</topic><topic>Penicillin</topic><topic>Polymerase chain reaction</topic><topic>Preschool children</topic><topic>Prevalence studies (Epidemiology)</topic><topic>Statistical analysis</topic><topic>Streptococcus infections</topic><topic>Streptococcus pneumoniae</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Meijing</creatorcontrib><creatorcontrib>Yao, Run</creatorcontrib><creatorcontrib>Yue, Huan</creatorcontrib><creatorcontrib>Zhang, Jingzhi</creatorcontrib><creatorcontrib>Chen, Min</creatorcontrib><creatorcontrib>Zhang, Weiwei</creatorcontrib><creatorcontrib>Liu, Daishun</creatorcontrib><creatorcontrib>Wu, Kaifeng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Saudi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Meijing</au><au>Yao, Run</au><au>Yue, Huan</au><au>Zhang, Jingzhi</au><au>Chen, Min</au><au>Zhang, Weiwei</au><au>Liu, Daishun</au><au>Wu, Kaifeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotype prevalence and antibiotic susceptibility patterns of pneumococcal isolates in Zunyi city, China</atitle><jtitle>Saudi medical journal</jtitle><addtitle>Saudi Med J</addtitle><date>2017-12</date><risdate>2017</risdate><volume>38</volume><issue>12</issue><spage>1243</spage><epage>1249</epage><pages>1243-1249</pages><issn>0379-5284</issn><eissn>1658-3175</eissn><abstract>To assess the serotype distribution and antimicrobial susceptibility of pneumococci isolated from inpatients of all ages suspected of having bacterial infections.
In this retrospective study, pneumococcal isolates were consecutively collected from the Third Affiliated Hospital of Zunyi Medical University, in Zunyi city, China, between January 2014 and December 2016. Pneumococci were identified using routine microbiological assays. We performed antimicrobial susceptibility analyses using the bacteria identification/susceptibility system VITEK2 and E-tests. Capsular types of all isolates were determined by multiplex polymerase chain reaction.
We identified 778 pneumococcal isolates. Serotypes 19F, 6A/6B, 19A, 23F, and 15B/15C were the most prevalent strains, accounting for 71.5% (556/778) of all isolates. Data show that 409 (70.4%) isolates could be covered by the PCV13 vaccine in children less than 2 years old. Irrespective of serotypes, 747 (96%) isolates were sensitive to penicillin, while 720 to 778 (90% to 100%) isolates were not susceptible to erythromycin, tetracycline, and trimethoprim/sulfamethoxazole. For isolates resistant to penicillin, ceftriaxone, cefotaxime, and meropenem, 22 to 39 (70% to 81.25%) strains belonged to PCV13 serotypes.
We found a substantial increase in the annual number of pneumococcal isolates since 2014. The theoretical impact of PCV13 was high in children less than 2 years old, and penicillin might be effective against pneumococcal infections in this region.</abstract><cop>Saudi Arabia</cop><pub>Saudi Medical Journal</pub><pmid>29209675</pmid><doi>10.15537/smj.2017.12.21090</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age groups Analysis Antibiotics Antimicrobial agents Bacterial infections Epidemiology FDA approval Microbial drug resistance Original Pediatrics Penicillin Polymerase chain reaction Preschool children Prevalence studies (Epidemiology) Statistical analysis Streptococcus infections Streptococcus pneumoniae Vaccines |
| title | Serotype prevalence and antibiotic susceptibility patterns of pneumococcal isolates in Zunyi city, China |
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