3D modeling of cancer stem cell niche
Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models...
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| Veröffentlicht in: | Oncotarget 2018-01, Vol.9 (1), p.1326-1345 |
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| container_title | Oncotarget |
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| creator | He, Jun Xiong, Li Li, Qinglong Lin, Liangwu Miao, Xiongying Yan, Shichao Hong, Zhangyong Yang, Leping Wen, Yu Deng, Xiyun |
| description | Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models have been developed. These
culture systems recapitulate the spatial dimension, cellular heterogeneity, and the molecular networks of the tumor microenvironment and show great promise in elucidating the pathophysiology of cancer stem cells and designing more clinically relavant treatment modalites. |
| doi_str_mv | 10.18632/oncotarget.19847 |
| format | Article |
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| ispartof | Oncotarget, 2018-01, Vol.9 (1), p.1326-1345 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free E- Journals; PubMed Central Open Access |
| subjects | Review |
| title | 3D modeling of cancer stem cell niche |
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