Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis

Colitis, an inflammatory disease of the digestive tract, is increasing in incidence and prevalence. Intestinal inflammation can occur as a consequence of dysfunctions in sphingolipid metabolism. In this study we used ceramide synthase 6 (CerS6) deficient mice, which have a reduced ability to generat...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.1627-9, Article 1627
Hauptverfasser:	Helke, Kristi, Angel, Peggi, Lu, Ping, Garrett-Mayer, Elizabeth, Ogretmen, Besim, Drake, Richard, Voelkel-Johnson, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	14/63 59/5 631/250/2504/223 631/250/256/2516 631/45/608 64/60 82/58 Animals Ceramide Colitis Colitis - chemically induced Colitis - pathology Colon Dextran Dextran Sulfate - administration & dosage Dextran Sulfate - toxicity Disease Models, Animal Enzymes Gastrointestinal tract Humanities and Social Sciences Inflammatory bowel disease Intestine Leukocytes (neutrophilic) Lipid metabolism Lymphocytes T Mice Mice, Knockout multidisciplinary Neutrophils Permeability Peroxidase Rodents Science Science (multidisciplinary) Sodium Sphingosine 1-phosphate Sphingosine N-Acyltransferase - deficiency
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