Vascular Semaphorin 7A Upregulation by Disturbed Flow Promotes Atherosclerosis Through Endothelial β1 Integrin

OBJECTIVE—Accumulating evidence suggests a role of semaphorins in vascular homeostasis. Here, we investigate the role of Sema7A (semaphorin 7A) in atherosclerosis and its underlying mechanism. APPROACH AND RESULTS—Using genetically engineered Sema7AApoE mice, we showed that deletion of Sema7A attenu...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2018-02, Vol.38 (2), p.335-343
Hauptverfasser:	Hu, Shuhong, Liu, Yifei, You, Tao, Heath, Jack, Xu, Linru, Zheng, Xiaowei, Wang, Aili, Wang, Yinyan, Li, Fengchan, Yang, Fei, Cao, Yiren, Zhang, Huayu, van Gils, Janine M, van Zonneveld, Anton Jan, Jo, Hanjoong, Wu, Qingyu, Zhang, Yonghong, Tang, Chaojun, Zhu, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD - metabolism Aortic Diseases - genetics Aortic Diseases - metabolism Aortic Diseases - pathology Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Carotid Artery Diseases - genetics Carotid Artery Diseases - metabolism Carotid Artery Diseases - pathology Cell Adhesion Cell Adhesion Molecules - metabolism Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Focal Adhesion Protein-Tyrosine Kinases - metabolism GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism Human Umbilical Vein Endothelial Cells Humans Integrin beta1 - metabolism Leukocyte Rolling MAP Kinase Kinase Kinases - metabolism Mechanotransduction, Cellular Mice, Inbred C57BL Mice, Knockout, ApoE NF-kappa B - metabolism Plaque, Atherosclerotic Regional Blood Flow Semaphorins - deficiency Semaphorins - genetics Semaphorins - metabolism THP-1 Cells Up-Regulation
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