Hepatic Gi signaling regulates whole-body glucose homeostasis

An increase in hepatic glucose production (HGP) is a key feature of type 2 diabetes. Excessive signaling through hepatic Gs-linked glucagon receptors critically contributes to pathologically elevated HGP. Here, we tested the hypothesis that this metabolic impairment can be counteracted by enhancing...

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Veröffentlicht in:	The Journal of clinical investigation 2018-02, Vol.128 (2), p.746-759
Hauptverfasser:	Rossi, Mario, Zhu, Lu, McMillin, Sara M, Pydi, Sai Prasad, Jain, Shanu, Wang, Lei, Cui, Yinghong, Lee, Regina J, Cohen, Amanda H, Kaneto, Hideaki, Birnbaum, Morris J, Ma, Yanling, Rotman, Yaron, Liu, Jie, Cyphert, Travis J, Finkel, Toren, McGuinness, Owen P, Wess, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Female Gene Expression Profiling Glucagon - metabolism Gluconeogenesis Glucose - metabolism GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Hepatocytes - cytology Hepatocytes - metabolism Homeostasis Humans Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Oxygen - chemistry Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Reactive Oxygen Species - metabolism Receptors, Glucagon - metabolism Signal Transduction
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