Multiplexed droplet single-cell RNA-sequencing using natural genetic variation

Droplet single-cell RNA-seq is applied to large numbers of pooled samples from unrelated individuals. Droplet single-cell RNA-sequencing (dscRNA-seq) has enabled rapid, massively parallel profiling of transcriptomes. However, assessing differential expression across multiple individuals has been ham...

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Veröffentlicht in:	Nature biotechnology 2018-01, Vol.36 (1), p.89-94
Hauptverfasser:	Kang, Hyun Min, Subramaniam, Meena, Targ, Sasha, Nguyen, Michelle, Maliskova, Lenka, McCarthy, Elizabeth, Wan, Eunice, Wong, Simon, Byrnes, Lauren, Lanata, Cristina M, Gate, Rachel E, Mostafavi, Sara, Marson, Alexander, Zaitlen, Noah, Criswell, Lindsey A, Ye, Chun Jimmie
Format:	Artikel
Sprache:	eng
Schlagworte:	38/43 45/91 49/62 631/114/2785 631/208/212/2019 Agriculture Bioinformatics Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cells Computer applications Computer simulation Gene expression Gene sequencing Genetic diversity Genetic variation Genetics Genotype Genotyping Harnesses High-Throughput Nucleotide Sequencing - methods Humans Interferon Interferons - therapeutic use Life Sciences Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - genetics Multiplexing Polymorphism Polymorphism, Single Nucleotide - genetics Quantitative Trait Loci - genetics Ribonucleic acid RNA RNA sequencing Single-Cell Analysis - methods Single-nucleotide polymorphism Software Transcriptome - genetics
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