Cerebral Perfusion Insufficiency and Relationships with Cognitive Deficits in Alzheimer’s Disease: A Multiparametric Neuroimaging Study
Micro- or macro-circulatory insufficiency has a negative impact in patients with Alzheimer’s disease (AD). This study used arterial spin-labeled magnetic resonance imaging (ASL-MRI) and ethylcysteinate dimer single-photon emission computed tomography (ECD-SPECT) in 50 patients with AD and 30 age-mat...
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| Veröffentlicht in: | Scientific reports 2018-01, Vol.8 (1), p.1541-14, Article 1541 |
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| creator | Huang, Chi-Wei Hsu, Shih-Wei Chang, Ya-Ting Huang, Shu-Hua Huang, Yung-Cheng Lee, Chen-Chang Chang, Wen-Neng Lui, Chun-Chung Chen, Na-Ching Chang, Chiung-Chih |
| description | Micro- or macro-circulatory insufficiency has a negative impact in patients with Alzheimer’s disease (AD). This study used arterial spin-labeled magnetic resonance imaging (ASL-MRI) and ethylcysteinate dimer single-photon emission computed tomography (ECD-SPECT) in 50 patients with AD and 30 age-matched controls to investigate how hypoperfusion patterns were associated with gray matter atrophy and clinical data. All participants completed 3DT1-MRI, ECD-SPECT and ASL-MRI examinations. Medial temporal cortex (MTC) volumes were correlated with regional signals showing significantly lower relative cerebral blood flow (rCBF) in ASL-MRI or perfusion index (PI) in ECD-SPECT. Neurobehavioral scores served as the outcome measures. Regions with lower PI showed spatial similarities with atrophy in the medial, anterior and superior temporal lobes, posterior cingulate cortex and angular gyrus, while regions showing lower rCBF were localized to the distal branches of posterior cerebral artery territories (posterior parietal and inferior temporal lobe) and watershed areas (angular gyrus, precuneus, posterior cingulate gyrus and middle frontal cortex). rCBF values in watershed areas correlated with MTC volumes and language composite scores. Precuneus and angular gyrus hypoperfusion were associated with the corresponding cortical atrophy. Macro- or micro-vasculature perfusion integrities and cortical atrophy determined the overall perfusion imaging topography and contributed differently to the clinical outcomes. |
| doi_str_mv | 10.1038/s41598-018-19387-x |
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This study used arterial spin-labeled magnetic resonance imaging (ASL-MRI) and ethylcysteinate dimer single-photon emission computed tomography (ECD-SPECT) in 50 patients with AD and 30 age-matched controls to investigate how hypoperfusion patterns were associated with gray matter atrophy and clinical data. All participants completed 3DT1-MRI, ECD-SPECT and ASL-MRI examinations. Medial temporal cortex (MTC) volumes were correlated with regional signals showing significantly lower relative cerebral blood flow (rCBF) in ASL-MRI or perfusion index (PI) in ECD-SPECT. Neurobehavioral scores served as the outcome measures. Regions with lower PI showed spatial similarities with atrophy in the medial, anterior and superior temporal lobes, posterior cingulate cortex and angular gyrus, while regions showing lower rCBF were localized to the distal branches of posterior cerebral artery territories (posterior parietal and inferior temporal lobe) and watershed areas (angular gyrus, precuneus, posterior cingulate gyrus and middle frontal cortex). rCBF values in watershed areas correlated with MTC volumes and language composite scores. Precuneus and angular gyrus hypoperfusion were associated with the corresponding cortical atrophy. Macro- or micro-vasculature perfusion integrities and cortical atrophy determined the overall perfusion imaging topography and contributed differently to the clinical outcomes.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-19387-x</identifier><identifier>PMID: 29367598</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/617/375/132/1283 ; 692/698/1688/64 ; Aged ; Aged, 80 and over ; Alzheimer Disease - complications ; Alzheimer's disease ; Atrophy ; Atrophy - pathology ; Blood flow ; Cerebral blood flow ; Cerebrovascular Disorders - complications ; Cerebrovascular Disorders - diagnostic imaging ; Cognition Disorders - physiopathology ; Cognitive ability ; Computed tomography ; Cortex (cingulate) ; Cortex (frontal) ; Cortex (parietal) ; Cortex (temporal) ; Female ; Gray Matter - pathology ; Humanities and Social Sciences ; Humans ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Middle Aged ; multidisciplinary ; Neurodegenerative diseases ; Neuroimaging ; NMR ; Nuclear magnetic resonance ; Perfusion ; Science ; Science (multidisciplinary) ; Single photon emission computed tomography ; Substantia grisea ; Temporal lobe ; Temporal Lobe - pathology ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Scientific reports, 2018-01, Vol.8 (1), p.1541-14, Article 1541</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-3af624653393441b8c43beb170694bb4d5703d69b7cc0ad93b28afa029c2e4da3</citedby><cites>FETCH-LOGICAL-c474t-3af624653393441b8c43beb170694bb4d5703d69b7cc0ad93b28afa029c2e4da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784155/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784155/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29367598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Chi-Wei</creatorcontrib><creatorcontrib>Hsu, Shih-Wei</creatorcontrib><creatorcontrib>Chang, Ya-Ting</creatorcontrib><creatorcontrib>Huang, Shu-Hua</creatorcontrib><creatorcontrib>Huang, Yung-Cheng</creatorcontrib><creatorcontrib>Lee, Chen-Chang</creatorcontrib><creatorcontrib>Chang, Wen-Neng</creatorcontrib><creatorcontrib>Lui, Chun-Chung</creatorcontrib><creatorcontrib>Chen, Na-Ching</creatorcontrib><creatorcontrib>Chang, Chiung-Chih</creatorcontrib><title>Cerebral Perfusion Insufficiency and Relationships with Cognitive Deficits in Alzheimer’s Disease: A Multiparametric Neuroimaging Study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Micro- or macro-circulatory insufficiency has a negative impact in patients with Alzheimer’s disease (AD). This study used arterial spin-labeled magnetic resonance imaging (ASL-MRI) and ethylcysteinate dimer single-photon emission computed tomography (ECD-SPECT) in 50 patients with AD and 30 age-matched controls to investigate how hypoperfusion patterns were associated with gray matter atrophy and clinical data. All participants completed 3DT1-MRI, ECD-SPECT and ASL-MRI examinations. Medial temporal cortex (MTC) volumes were correlated with regional signals showing significantly lower relative cerebral blood flow (rCBF) in ASL-MRI or perfusion index (PI) in ECD-SPECT. Neurobehavioral scores served as the outcome measures. 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Macro- or micro-vasculature perfusion integrities and cortical atrophy determined the overall perfusion imaging topography and contributed differently to the clinical outcomes.</description><subject>692/617/375/132/1283</subject><subject>692/698/1688/64</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer's disease</subject><subject>Atrophy</subject><subject>Atrophy - pathology</subject><subject>Blood flow</subject><subject>Cerebral blood flow</subject><subject>Cerebrovascular Disorders - complications</subject><subject>Cerebrovascular Disorders - diagnostic imaging</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cognitive ability</subject><subject>Computed tomography</subject><subject>Cortex (cingulate)</subject><subject>Cortex (frontal)</subject><subject>Cortex (parietal)</subject><subject>Cortex (temporal)</subject><subject>Female</subject><subject>Gray Matter - pathology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Neurodegenerative diseases</subject><subject>Neuroimaging</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Perfusion</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Single photon emission computed tomography</subject><subject>Substantia grisea</subject><subject>Temporal lobe</subject><subject>Temporal Lobe - 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complications</topic><topic>Alzheimer's disease</topic><topic>Atrophy</topic><topic>Atrophy - pathology</topic><topic>Blood flow</topic><topic>Cerebral blood flow</topic><topic>Cerebrovascular Disorders - complications</topic><topic>Cerebrovascular Disorders - diagnostic imaging</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cognitive ability</topic><topic>Computed tomography</topic><topic>Cortex (cingulate)</topic><topic>Cortex (frontal)</topic><topic>Cortex (parietal)</topic><topic>Cortex (temporal)</topic><topic>Female</topic><topic>Gray Matter - pathology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Neurodegenerative diseases</topic><topic>Neuroimaging</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Perfusion</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Single photon emission computed tomography</topic><topic>Substantia grisea</topic><topic>Temporal lobe</topic><topic>Temporal Lobe - pathology</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Chi-Wei</creatorcontrib><creatorcontrib>Hsu, Shih-Wei</creatorcontrib><creatorcontrib>Chang, Ya-Ting</creatorcontrib><creatorcontrib>Huang, Shu-Hua</creatorcontrib><creatorcontrib>Huang, Yung-Cheng</creatorcontrib><creatorcontrib>Lee, Chen-Chang</creatorcontrib><creatorcontrib>Chang, Wen-Neng</creatorcontrib><creatorcontrib>Lui, Chun-Chung</creatorcontrib><creatorcontrib>Chen, Na-Ching</creatorcontrib><creatorcontrib>Chang, Chiung-Chih</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Chi-Wei</au><au>Hsu, Shih-Wei</au><au>Chang, Ya-Ting</au><au>Huang, Shu-Hua</au><au>Huang, Yung-Cheng</au><au>Lee, Chen-Chang</au><au>Chang, Wen-Neng</au><au>Lui, Chun-Chung</au><au>Chen, Na-Ching</au><au>Chang, Chiung-Chih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral Perfusion Insufficiency and Relationships with Cognitive Deficits in Alzheimer’s Disease: A Multiparametric Neuroimaging Study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-01-24</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>1541</spage><epage>14</epage><pages>1541-14</pages><artnum>1541</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Micro- or macro-circulatory insufficiency has a negative impact in patients with Alzheimer’s disease (AD). This study used arterial spin-labeled magnetic resonance imaging (ASL-MRI) and ethylcysteinate dimer single-photon emission computed tomography (ECD-SPECT) in 50 patients with AD and 30 age-matched controls to investigate how hypoperfusion patterns were associated with gray matter atrophy and clinical data. All participants completed 3DT1-MRI, ECD-SPECT and ASL-MRI examinations. Medial temporal cortex (MTC) volumes were correlated with regional signals showing significantly lower relative cerebral blood flow (rCBF) in ASL-MRI or perfusion index (PI) in ECD-SPECT. Neurobehavioral scores served as the outcome measures. Regions with lower PI showed spatial similarities with atrophy in the medial, anterior and superior temporal lobes, posterior cingulate cortex and angular gyrus, while regions showing lower rCBF were localized to the distal branches of posterior cerebral artery territories (posterior parietal and inferior temporal lobe) and watershed areas (angular gyrus, precuneus, posterior cingulate gyrus and middle frontal cortex). rCBF values in watershed areas correlated with MTC volumes and language composite scores. Precuneus and angular gyrus hypoperfusion were associated with the corresponding cortical atrophy. Macro- or micro-vasculature perfusion integrities and cortical atrophy determined the overall perfusion imaging topography and contributed differently to the clinical outcomes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29367598</pmid><doi>10.1038/s41598-018-19387-x</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/617/375/132/1283 692/698/1688/64 Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer's disease Atrophy Atrophy - pathology Blood flow Cerebral blood flow Cerebrovascular Disorders - complications Cerebrovascular Disorders - diagnostic imaging Cognition Disorders - physiopathology Cognitive ability Computed tomography Cortex (cingulate) Cortex (frontal) Cortex (parietal) Cortex (temporal) Female Gray Matter - pathology Humanities and Social Sciences Humans Magnetic Resonance Imaging Male Medical imaging Middle Aged multidisciplinary Neurodegenerative diseases Neuroimaging NMR Nuclear magnetic resonance Perfusion Science Science (multidisciplinary) Single photon emission computed tomography Substantia grisea Temporal lobe Temporal Lobe - pathology Tomography, Emission-Computed, Single-Photon |
| title | Cerebral Perfusion Insufficiency and Relationships with Cognitive Deficits in Alzheimer’s Disease: A Multiparametric Neuroimaging Study |
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