IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis

Mycobacterium tuberculosis ( Mtb ) is a life-threatening pathogen in humans. Bacterial infection of macrophages usually triggers strong innate immune mechanisms, including IL-1 cytokine secretion. The newer member of the IL-1 family, IL-36, was recently shown to be involved in cellular defense again...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.1520-13, Article 1520
Hauptverfasser:	Ahsan, Fadhil, Maertzdorf, Jeroen, Guhlich-Bornhof, Ute, Kaufmann, Stefan H. E., Moura-Alves, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/21 13/95 14 14/63 38 38/61 38/77 38/89 631/250/127/1213 631/250/255/1856 631/250/262/2106 96 Antibacterial activity Antimicrobial Cationic Peptides - biosynthesis Antimicrobial peptides Bacterial diseases Biosynthesis Cholesterol Cholesterol - metabolism HEK293 Cells Host-Pathogen Interactions Humanities and Social Sciences Humans Immune system Interleukin 1 Interleukin-1 - metabolism Lipid metabolism Liver X receptors Liver X Receptors - metabolism Macrophages Macrophages - immunology Macrophages - microbiology Metabolism multidisciplinary Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Peptides Science Science (multidisciplinary) THP-1 Cells Tuberculosis Tuberculosis - immunology
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