Leptin action in normal and pathological pregnancies
Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto‐placental communication. Leptin is a peptide hormone secreted mainly by adi...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2018-02, Vol.22 (2), p.716-727 |
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| creator | Pérez‐Pérez, Antonio Toro, Ayelén Vilariño‐García, Teresa Maymó, Julieta Guadix, Pilar Dueñas, José L. Fernández‐Sánchez, Manuel Varone, Cecilia Sánchez‐Margalet, Víctor |
| description | Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto‐placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin‐producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre‐eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy. |
| doi_str_mv | 10.1111/jcmm.13369 |
| format | Article |
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Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin‐producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre‐eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.13369</identifier><identifier>PMID: 29160594</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Adipose tissue ; Adipose Tissue - metabolism ; Apoptosis ; Autocrine signalling ; Cell proliferation ; Deregulation ; Diabetes mellitus ; Female ; Gestation ; gestational diabetes ; Gonadotropins ; growth restriction ; Health risk assessment ; Humans ; Immunologic Factors - metabolism ; Implantation ; Leptin ; Leptin - metabolism ; Paracrine signalling ; Pituitary (anterior) ; Placenta ; Placenta - embryology ; Placenta - metabolism ; Polycystic ovary syndrome ; Pre-eclampsia ; Preeclampsia ; Pregnancy ; Pregnancy Complications - metabolism ; Protein biosynthesis ; Protein synthesis ; recurrent miscarriage ; Reproduction ; Reproductive system ; Review ; Reviews</subject><ispartof>Journal of cellular and molecular medicine, 2018-02, Vol.22 (2), p.716-727</ispartof><rights>2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5559-95000c5ed904d90fbca7d48285396c8a8a131d9416c8968e2fd728c062d921803</citedby><cites>FETCH-LOGICAL-c5559-95000c5ed904d90fbca7d48285396c8a8a131d9416c8968e2fd728c062d921803</cites><orcidid>0000-0001-8638-8680</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783877/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783877/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29160594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez‐Pérez, Antonio</creatorcontrib><creatorcontrib>Toro, Ayelén</creatorcontrib><creatorcontrib>Vilariño‐García, Teresa</creatorcontrib><creatorcontrib>Maymó, Julieta</creatorcontrib><creatorcontrib>Guadix, Pilar</creatorcontrib><creatorcontrib>Dueñas, José L.</creatorcontrib><creatorcontrib>Fernández‐Sánchez, Manuel</creatorcontrib><creatorcontrib>Varone, Cecilia</creatorcontrib><creatorcontrib>Sánchez‐Margalet, Víctor</creatorcontrib><title>Leptin action in normal and pathological pregnancies</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto‐placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin‐producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre‐eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Apoptosis</subject><subject>Autocrine signalling</subject><subject>Cell proliferation</subject><subject>Deregulation</subject><subject>Diabetes mellitus</subject><subject>Female</subject><subject>Gestation</subject><subject>gestational diabetes</subject><subject>Gonadotropins</subject><subject>growth restriction</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Immunologic Factors - metabolism</subject><subject>Implantation</subject><subject>Leptin</subject><subject>Leptin - metabolism</subject><subject>Paracrine signalling</subject><subject>Pituitary (anterior)</subject><subject>Placenta</subject><subject>Placenta - embryology</subject><subject>Placenta - metabolism</subject><subject>Polycystic ovary syndrome</subject><subject>Pre-eclampsia</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - metabolism</subject><subject>Protein biosynthesis</subject><subject>Protein synthesis</subject><subject>recurrent miscarriage</subject><subject>Reproduction</subject><subject>Reproductive system</subject><subject>Review</subject><subject>Reviews</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUtLAzEUhYMotlY3_gApuBGhNY9JJtkIUnzS4kbXIc2kbcpMMiYzSv-9qa1FXRgIuTf5OJybA8ApgkOU1tVSV9UQEcLEHugiyvEgEyTb39aIE94BRzEuISQMEXEIOlggBqnIuiAbm7qxrq90Y73rp8r5UKmyr1zRr1Wz8KWfW50u6mDmTjltTTwGBzNVRnOyPXvg9e72ZfQwGD_fP45uxgNNKRUDQSGEmppCwCzt2VSrvMg45pQIprniChFUiAylRjBu8KzIMdeQ4UJgxCHpgeuNbt1OK1No45qgSlkHW6mwkl5Z-fvF2YWc-3dJ8zR0nieBi61A8G-tiY2sbNSmLJUzvo0SCcYEx2tHPXD-B136Nrg0XqIEZDliDCfqckPp4GMMZrYzg6BchyHXYcivMBJ89tP-Dv3-_QSgDfBhS7P6R0o-jSaTjegnrbOTdg</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Pérez‐Pérez, Antonio</creator><creator>Toro, Ayelén</creator><creator>Vilariño‐García, Teresa</creator><creator>Maymó, Julieta</creator><creator>Guadix, Pilar</creator><creator>Dueñas, José L.</creator><creator>Fernández‐Sánchez, Manuel</creator><creator>Varone, Cecilia</creator><creator>Sánchez‐Margalet, Víctor</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8638-8680</orcidid></search><sort><creationdate>201802</creationdate><title>Leptin action in normal and pathological pregnancies</title><author>Pérez‐Pérez, Antonio ; Toro, Ayelén ; Vilariño‐García, Teresa ; Maymó, Julieta ; Guadix, Pilar ; Dueñas, José L. ; Fernández‐Sánchez, Manuel ; Varone, Cecilia ; Sánchez‐Margalet, Víctor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5559-95000c5ed904d90fbca7d48285396c8a8a131d9416c8968e2fd728c062d921803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez‐Pérez, Antonio</au><au>Toro, Ayelén</au><au>Vilariño‐García, Teresa</au><au>Maymó, Julieta</au><au>Guadix, Pilar</au><au>Dueñas, José L.</au><au>Fernández‐Sánchez, Manuel</au><au>Varone, Cecilia</au><au>Sánchez‐Margalet, Víctor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin action in normal and pathological pregnancies</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2018-02</date><risdate>2018</risdate><volume>22</volume><issue>2</issue><spage>716</spage><epage>727</epage><pages>716-727</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto‐placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin‐producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre‐eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>29160594</pmid><doi>10.1111/jcmm.13369</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-8638-8680</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose tissue Adipose Tissue - metabolism Apoptosis Autocrine signalling Cell proliferation Deregulation Diabetes mellitus Female Gestation gestational diabetes Gonadotropins growth restriction Health risk assessment Humans Immunologic Factors - metabolism Implantation Leptin Leptin - metabolism Paracrine signalling Pituitary (anterior) Placenta Placenta - embryology Placenta - metabolism Polycystic ovary syndrome Pre-eclampsia Preeclampsia Pregnancy Pregnancy Complications - metabolism Protein biosynthesis Protein synthesis recurrent miscarriage Reproduction Reproductive system Review Reviews |
| title | Leptin action in normal and pathological pregnancies |
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